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Basic and Clinical Neuroscience، جلد ۱۴، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Introducing Albumin and Interleukin 6 As Common Critical Dysregulated Protein Between Migraine and Gliosarcoma |
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| چکیده انگلیسی مقاله |
Introduction: It is reported that migraine may be risk factor of brain cancers. Since the one of the best ways to assess this possible relationship is molecular mechanism study, here the common central dysregulated proteins between these diseases are investigated via network analysis. Methods: The dysregulated proteins of migraine and gliosarcoma are extracted from STRING database and interacted via Cytoscape software to form two separate networks. Central nodes of the networks are compared to find the common central differentially expressed proteins. First neighbors of the common central proteins are studied. Results: Numbers of 11 hub-bottlenecks for each one of migraine and gliosarcoma cancer networks were identified. Albumin and interleukin 6 as common differentially expressed central proteins were introduced. KNG1, VEGFA, and NF1 the first neighbors of ALB-IL6 were connected to the central nodes of networks of the two studied diseases. Conclusion: ALB and IL6 can be considered as molecular linkers between migraine and brain cancers. |
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| کلیدواژه‌های انگلیسی مقاله |
Migraine, Gliosarcoma, Albumin, Interleukin 6, Network analysis |
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| نویسندگان مقاله |
| Babak Arjmand
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
| Vahid Mansouri
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Maryam Hamzeloo Moghadam
Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Sina Rezaei Tavirani
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1483-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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