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، جلد ۱۷، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Synergistic Glucose-lowering Effects of Metformin and Bavachinin on Type II Diabetic Rats |
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| چکیده انگلیسی مقاله |
Background: Diabetes is one of the most prevalent endocrine disorders in humans, and its first-line medication is Metformin. Peroxisome proliferator-activated receptor gamma (PPAR–γ) agonists are the adjuncts to Metformin. Bavachinin is a PPAR pan-agonist with fewer side effects than Metformin. In this study, the synergistic effects of Metformin and Bavachinin were investigated on type II diabetic rats. Methods: After four weeks of a high fat and glucose diet, type II diabetes was induced in 28 male Wistar rats, using injection of streptozotocin and nicotinamide. The animals were distributed into five groups of seven each: 1)normal control (N), 2)diabetic control (D), 3)diabetic rats receiving Metformin (DM),4)Bavachinin (DB), and 5) Metformin plus Bavachinin (DMB). Oral glucose tolerance test (OGTT), fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of β-cell function (HOMA-β), homeostasis model assessment of insulin resistance (HOMA-IR), and insulin sensitivity index (ISI) were obtained. Results: The OGTT results in DM, DB, and DMB groups were significantly improved compared to that of D group. The FBG levels were significantly lower in DMB than in DB, DM, and D groups. The FINS levels of DMB were significantly less than those of DB, DM, and D groups. The HOMA-IR and HOMA-β were comparable between DMB and N groups. The ISI improved significantly in DMB compared to those in DM, DB, and D groups. Conclusions: Bavachinin may be used combined with Metformin for the treatment of type II diabetes at lower doses of Metformin, thus having fewer side effects. |
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| کلیدواژه‌های انگلیسی مقاله |
Bavachinin, Diabetes Mellitus Type 2, Insulin resistance, Metabolic syndrome, Metformin |
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| نویسندگان مقاله |
| Sara Kosraviani
Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
| Ali Emami
Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
| Samaneh Keshavarz Hedayati
Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Science, Qazvin, Iran
| Sanaz Keshavarz Shahbaz
Cellular and Molecular Research Center, Research Institute for Prevention of Noncommunicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
| Ehsan Aali
Cellular and Molecular Research Center, Research Institute for Prevention of Noncommunicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
| Yazdan Naderi
Cellular and Molecular Research Center, Research Institute for Prevention of Noncommunicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-833-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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