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Caspian Journal of Neurological Sciences، جلد ۹، شماره ۳، صفحات ۴-۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Abductor Pollicis Brevis/Abductor Digiti Minimi Compound Muscle Action Potential Ratio as a Diagnostic Marker for Amyotrophic Lateral Sclerosis |
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| چکیده انگلیسی مقاله |
Background: We aimed to assess the diagnostic utility of abductor pollicis brevis/abductor digiti minimi compound muscle action potentials (APB/ADM CMAP) ratio as an indicator of split hand phenomenon in the differentiation of amyotrophic lateral sclerosis (ALS) patients from healthy controls. Objectives: To assess diagnostic utility of APB/ADM CMAP ratio as an indicator split hand phenomenon in differentiation of ALS patients from healthy controls. Materials & Methods: This cross-sectional retrospective study was conducted at Alzahra and Kashani hospitals of Isfahan, Iran, in 2021. The study population consisted of all patients with definite diagnoses of ALS who had undergone electrophysiological studies within the previous 5 years. APB/ADM CMAP ratio was calculated in both groups based on right/left hand and below/ over 50 years of age. The statistical analysis also evaluated the diagnostic accuracy of the APB/ ADM amplitude ratio. Results: A total of 200 ALS patients and 200 healthy controls were evaluated. APB/ADM ratios of the right hand in the controls and patients were 1.27±0.71 and 1.27±1.69 (P=0.961), while in the left hand, these figures were 1.30±0.54 and 1.11±0.97, respectively (P=0.018). Analysis based on age group revealed a significant difference in the APB/ADM amplitude ratio in the left hand of individuals younger than 50. The cut-off points of 0.81 (sensitivity=86.2% and specificity=58.7%) and 1.03 (sensitivity=72.5% and specificity=58.5%) were calculated for right and left hands, respectively. Conclusion: APB/ADM CMAP ratio is a relatively highly sensitive but moderately specific diagnostic marker for differentiating ALS patients from healthy controls with higher diagnostic utility in patients younger than 50. |
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| کلیدواژه‌های انگلیسی مقاله |
Muscle atrophy, Amyotrophic lateral sclerosis, Split hand |
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| نویسندگان مقاله |
| Majid Ghasemi
Department of Neurology, Isfahan Neuroscience Research Center, Isfahan University of Medical Science, Isfahan, Iran.
| Maryam Alizadeh
Department of Neurology, Isfahan Neuroscience Research Center, Alzahra Research Institute, Isfahan University of Medical Science, Isfahan, Iran.
| Keyvan Basiri
Department of Neurology, Isfahan Neuroscience Research Center, Alzahra Research Institute, Isfahan University of Medical Science, Isfahan, Iran.
| Behnaz Ansari
Department of Neurology, Isfahan Neuroscience Research Center, Alzahra Research Institute, Isfahan University of Medical Science, Isfahan, Iran.
| Reza Tayebi Khorami
Department of Mathematics , Ahvaz Branch , Islamic Azad University , Ahvaz , Iran.
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| نشانی اینترنتی |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-200&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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