سامانه اطلاعات پژوهشی ایران - NRIP Journals

پنجشنبه 30 مرداد 1404


Caspian Journal of Neurological Sciences، جلد ۱، شماره ۳، صفحات ۱-۱۰


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چکیده فارسی مقاله

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عنوان انگلیسی	The Involvement of Nitric Oxide in Antidepressant-Like Effect of Metformin after Bile-Duct Ligation in NMRI Mice

چکیده انگلیسی مقاله	Background: In some disorders such as diabetes mellitus patients can display depressive symptoms. Metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. Objective: Current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (NO) in this way, in an experimental animal model of cholestasis in NMRI (Naval Medical Research Institute) mice. Materials and Methods: Bile duct ligated (BDL) and sham-operated mice were forced to swim separately and the effect of metformin on immobility time in the last 4 minutes of the 6 minutes test was assessed. To evaluate the probable participation of NO, N-nitro-L-arginine methyl ester (L-NAME) a non-specific NO synthase inhibitor and aminoguanidine, a specific iNO synthase inhibitor were injected acutely to metformin-treated BDL mice and then their immobility time was calculated in forced swimming test (FST). Results: The immobility time significantly reduced after bile-duct ligation and metformin-treatment decreased this time additionally. L-NAME but not amino-guanidine administration significantly inhibited antidepressant like property of metformin in BDL mice. We have displayed that NO overproduction by metformin in cholestatic mice produce an anti-depressant like effect, causing a decrease in the mice immobility time in FST. Conclusion: Metformin pretreatment can decrease depression in cholestatic mice through an NO dependent pathway.

کلیدواژه‌های انگلیسی مقاله

نویسندگان مقاله	ستار ستار \| sattar ostadhadi experimental medicine research center, tehran university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences) سمانه جهان آبادی \| samaneh jahanabadi experimental medicine research center, tehran university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences) شیوا جوادی \| shiva javadi experimental medicine research center, tehran university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences) hnaneh saadaei \| hnaneh saadaei experimental medicine research center, tehran university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences) سمیرا ذوالفقاری \| samira zolfaghari department of tissue engineering and applied cell sciences, school of advanced technologies in medicine, iran university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences) احمدرضا دهپور \| ahmad reza dehpour experimental medicine research center, tehran university of medical sciences, tehran, iran; dehpour@yahoo.com سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی	http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-19&slc_lang=en&sid=en
فایل مقاله	اشکال در دسترسی به فایل - ./files/site1/rds_journals/1782/article-1782-282252.pdf
کد مقاله (doi)
زبان مقاله منتشر شده	en
موضوعات مقاله منتشر شده	تخصصی
نوع مقاله منتشر شده	پژوهشی

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