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Pharmaceutical and Biomedical Research، جلد ۲، شماره ۱، صفحات ۸-۱۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Quantification of thymol content in different extracts of Zataria multiflora by HPLC method |
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| چکیده انگلیسی مقاله |
Zataria multiflora Boiss is used in traditional folk remedies as antiseptic, analgesic, carminative, anthelmintic medication. The main components of Zataria multiflora are phenolic compounds such as thymol and carvacrol. The aim of this study was developed a simple and rapid method for determination of the thymol in different extracts of Zataria multiflora by HPLC method. The dried aerial parts of Zataria multiflora in the flowering stage was extracted with ethanol 34%, 42% and 70% for 48 hours. Several mobile phase systems were applied for development and separation of thymol and carvacrol that have close retention time in HPLC system. The peaks of thymol and carvacrol are successfully separated in acetonitrile-water-acetic acid mobile phase. Thymol and carvacrol were separated with a retention times 10.4 and 9.8 minutes respectively, in an isocratic solvent system with HPLC. Thymol content was 2.7 ± 0.06, 3.7 ± 0.07 and 6.0 ± 0.11 mg/g, in ethanol at concentration of 34%, 42% and 70%, respectively. Thymol content in different hydroalcoholic extract of Zataria multiflora is dependent to ethanol concentration in extraction solvent. |
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| کلیدواژه‌های انگلیسی مقاله |
Zataria multiflora, thymol, carvacrol, HPLC. |
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| نویسندگان مقاله |
آذر آقامحمدی | azar aghamohammadi
department of radiopharmacy, faculty of pharmacy, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
محمد آزادبخت | mohammad azadbakht
department of radiopharmacy, faculty of pharmacy, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
سید جلال حسینی مهر | seyed jalal hosseinimehr
department of radiopharmacy, faculty of pharmacy, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-25-3&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1789/article-1789-282440.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فیتوشیمی |
| نوع مقاله منتشر شده |
پژوهشی |
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