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Pharmaceutical and Biomedical Research، جلد ۲، شماره ۱، صفحات ۴۴-۵۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Encapsulation of nystatin in nanoliposomal formulation: characterization, stability study and antifungal activity against Candida albicans |
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| چکیده انگلیسی مقاله |
In this study, nystatin liposomal formulation was prepared and characterized. The physicochemical properties of formulations including vesicle size, drug entrapment stability and in vitro release were studied. The highest entrapment efficiency of nystatin into liposomes was obtained about 70% when cholesterol (CHO) was added to the formulations prepared with dipalmitoylphosphatidylcholine. In addition, the drug entrapment efficiency was decreased when distearoylphosphatidylcholine was used but it was improved by addition of CHO and hydration with 9% sucrose solution. Liposomes with uniform size distribution and average size of 100 nm were produced. Long term stability study indicated that the lyophilized liposomal nystatin was physically stable for at least 6 months at 4 C. In vitro anti-fungal activity of liposomal nystatin was found to be more effective than free nystatin against Candida albicans. |
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| نویسندگان مقاله |
ابراهیم سعادت | ebrahim saadat
department of pharmaceutics, faculty of pharmacy, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
رسول دیناروند | rassoul dinarvand
department of pharmaceutics, faculty of pharmacy, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
پدرام ابراهیم نژاد | pedram ebrahimnejad
department of pharmaceutics, faculty of pharmacy, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-62-2&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1789/article-1789-282444.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماسیوتیکس |
| نوع مقاله منتشر شده |
پژوهشی |
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