| چکیده انگلیسی مقاله |
It has long been known that Methamphetamine (METH), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could improve cognitive performance in several neurodegenerative diseases. The present study investigates the effects of lithium on spatial learning and memory, using the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema in METH-exposed male Wistar rats. The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in METH-exposed rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and neuronal apoptosis in the CA1 region in METH -exposed rats. The results suggest that treatment with lithium can partially ameliorate the cognitive impairments induced by METH in rats, which may be associated with its neuroprotective effect in the hippocampus. |
| نویسندگان مقاله |
| Hamed Ghazvini
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
| Fatemeh Tirgar
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
| Mehdi Khodamoradi
Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
| Seyedeh Masoumeh Seyedhosseini Tamijani
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
| Saba Niknamfar
Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
| Esmaeil Akbari
Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
| Mohammad Nekahi
Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
| Nabiollah Tarjani
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
| Hossein Ghalehnoei
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
| Motahareh Rouhi Ardeshiri
Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
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