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Immunoregulation، جلد ۴، شماره ۲، صفحات ۸۳-۹۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
No Alternation in Treg Frequency in Peripheral Blood of Chrmical Vitems With Long-term Mild-moderate Pulmonary Complication |
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| چکیده انگلیسی مقاله |
Background: Regulatory T Cells (Treg) are the subgroups of lymphocytes that control inflammatory responses and regulate homeostasis processes through cellular contact and the secretion of soluble agents. We investigated the frequency of Treg in peripheral blood of sulfur mustard exposed patients with CD4, CD25, CD127, FOXP3, and CD45RA markers, compared with healthy individuals and the correlation between frequency of these cells and long-term pulmonary complications.
Materials and Methods: In total, 12 sulfur mustard exposed patients and 12 healthy volunteers were invited. Clinical inspections of both groups were performed by pulmonary specialists and spyrometric evaluation that pulmonary function test operators conducted. After the isolation of peripheral blood mononuclear cells, the frequency of Treg cells was determined by flowcytometry.
Results: The frequency of Treg cells was not significantly different in those exposed to sulfur mustard. Furthermore, there was no significant correlation between spyrometric parameters and the frequency of these cells.
Conclusion: According to the current study data, there is no difference in the frequency of Treg cells between exposed patients with mild pulmonary complications and healthy volunteers. Thus, further studies are required to understand the role of these cells in the severity of pulmonary complications of these patients. |
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| کلیدواژههای انگلیسی مقاله |
Regulatory T cells,
Sulfur Mustard,
Bioterrorism,
Chemical warfare |
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| نویسندگان مقاله |
Nafiseh Zand |
Department of Immunology, School of Medicine, Shahed University, Tehran, Iran.
Mahmood Bozorgmehr |
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Ali Reza Sabetpour |
Countess of Chester Hospital, Chester, UK.
Mohammad Mahdi Naghizadeh |
Noncommuicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Ensieh Sadat Mirsharif |
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Tooba Ghazanfari |
Department of Immunology, School of Medicine, Shahed University, Tehran, Iran.
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| نشانی اینترنتی |
https://immunoreg.shahed.ac.ir/article_3605_649b7cbae5142ea130e805e3f25d331e.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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| نوع مقاله منتشر شده |
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