| چکیده انگلیسی مقاله |
Introduction: Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of the central nervous system, which is associated with brain atrophy and volume changes in some brain structures. This study aimed to compare the volume of the basal ganglia, thalamus, cerebellum, and brainstem in patients with relapsing-remitting multiple sclerosis with that of the control group using magnetic resonance imaging (MRI).
Methods: In this cross-sectional study, MRI brain scans were obtained from 25 patients with relapsing-remitting and 25 healthy control subjects. Volumetric analyses were performed using Brain Suite software.
Results: The mean ages ± standard deviation (SD) of the MS and the control groups were 33.96±8.75 and 40.40±8.72, respectively. No statistically significant difference was found in gender distribution (p=0.747). The bilateral putamen and caudate nuclei volumes were significantly higher in the case group than in the control group (p<0.001). Moreover, lower volume of brainstem and cerebellum and bilateral thalamus and globus pallidus were identified in the MS patients, compared to the control group (p<0.001). There was an inverse correlation between the disease and treatment duration with the thalamus and cerebellum volume in MS patients (p=0.001). Treatment duration also had an inverse correlation with brainstem volume (p=0.047).
Conclusion: The findings indicate that the volume of some structures of the brain including globus pallidus and thalamus and cerebellum and brainstem is lower in MS and can be one of the markers of disease progression and disability among MS patients. |
| کلیدواژههای انگلیسی مقاله |
Magnetic resonance imaging, Volume, Basal ganglia, Cerebellum, Brainstem, Multiple sclerosis |
| نویسندگان مقاله |
| Sima Fallah Arzpeyma
Departments of Radiology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Sara Janeshin
Departments of Radiology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Niusheh Soofi Afshar
Departments of Radiology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Alia Saberi
Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Hamidreza Ghalyanchi Langroodi
Clinical Development Research Unit of Ghaem Hospital, Rasht, Iran.
| Mohammad Ebrahim Ghaffari
Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Kamal AmirAshjei
Clinical Research Development Unit of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
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