|
|
، جلد ۸، شماره ۳، صفحات ۲۱۲-۲۱۷
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Pharmacokinetics of cefpirome in buffalo calves (Bubalus bubalis) following single intramuscular
administration |
|
| چکیده انگلیسی مقاله |
The pharmacokinetics of cefpirome was investigated in buffalo calves following its single intramuscular (IM) administration (10 mg). The peak plasma concentration of cefpirome at 30 min was 9.0 ± 0.5 μg.ml-1, which declined to 0.2 ± 0.1 μg.ml -1 at 24 hrs. The absorption half-life (t1/2Ka) and elimination half-life (t1/2 β) were 0.19 ± 0.03 hr and 2.39 ± 0.05 hr, respectively. The area under the plasma concentration-time curve (AUC), area under the first moment curve (AUMC), apparent volume of distribution (Vd area), total body clearance (ClB), mean residence time (MRT) and total duration of therapeutic effect (td) were 28.7 ± 1.9μg.ml-1.hr, 107.7 ± 6.7 μg.ml-1.hr2, 0.42 ± 0.01 L.kg-1, 0.12 ± 0.003 L.kg-1.hr-1, 3.76 ± 0.04 hr and 12.7 ± 0.3 hr, respectively. The systemic bioavailability (F) after IM administration of cefpirome in calves was 35.3 ±3.1%. To maintain a minimum therapeutic concentration of 0.25 μg.ml-1, a satisfactory dosage regimen of cefpirome in buffalo calves was 3.46 mg.kg-1 followed by 3.36 mg.kg-1 at 12-hour intervals. Cefpirome was bound to the plasma proteins of buffalo calves in vitro to the extent of 30.7 ± 1.9%
|
|
| کلیدواژه‌های انگلیسی مقاله |
Buffalo, Cefpirome, Cephalosporins, Dosage, pharmacokinetics |
|
| نویسندگان مقاله |
N. Rajput |
Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary
and Animal Sciences University, Ludhiana, India
V. K. Dumka |
Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary
and Animal Sciences University, Ludhiana, India
H. S. Sandhu |
Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary
and Animal Sciences University, Ludhiana, India
|
|
| نشانی اینترنتی |
http://ijvr.shirazu.ac.ir/article_926_5df6d53bad5b5212fddbbe8aabac8ee0.pdf |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|