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Immunoregulation، جلد ۵، شماره ۲، صفحات ۷۳-۹۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Type I Interferon and COVID-19 |
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| چکیده انگلیسی مقاله |
Upon viral infection, the release of type I interferons (IFNs) plays a crucial role in limiting viral replication, reducing tissue damage, and boosting both innate and adaptive immune responses. A plasmacytoid dendritic cell (pDC) is a professional type I IFN-producing cell with the ability to produce large amounts of type I IFN quickly. However, when pDCs experience dysfunction or impairment in their ability to produce type I IFNs, the susceptibility to severe viral infections increases. Patients with severe COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibit lower levels of pDCs and diminished type I IFN responses compared to individuals with mild or asymptomatic disease. This association between severe COVID-19 and compromised IFN responses extends beyond underlying chronic illnesses. This review will also discuss the dysregulation of the pDC/type I IFN axis in COVID-19 and highlight the critical role of type I IFN-dependent factors contributing to the severity of COVID-19. Additionally, the impact of the IFN signature on a patient’s immune response to SARS-CoV-2 infection will be investigated. |
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| کلیدواژههای انگلیسی مقاله |
Plasmacytoid dendritic cell,
Type I interferon,
COVID-19,
SARS-CoV-2,
Antiviral response,
Risk factor,
IFN signature |
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| نویسندگان مقاله |
Bahman Rahimlou |
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Mohammad Reza Ghazanfari |
Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran.
Niki Ghambari Mohammadi |
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
https://immunoreg.shahed.ac.ir/article_4319_bbf0a9912adb25d0820c5b73381bd4d2.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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