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Caspian Journal of Neurological Sciences، جلد ۱۰، شماره ۲، صفحات ۱۰۲-۱۱۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression |
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| چکیده انگلیسی مقاله |
Background: Depression is a serious mental illness with symptoms such as worry, disturbed sleep and appetite, lack of interest or pleasure, and persistent sorrow.
Objectives: This study aims to assess the effect of fluvoxamine (FLX) on behavioral and electrophysiological alterations of the posterior cingulate cortex (PCC) and the hippocampus in rats with depression.
Materials & Methods: Thirty-two albino rats (weighing 250–300 g) were divided into four groups; control (sham), chronic mild stress (CMS), FLX, and CMS+FLX. The CMS was induced by applying different stressors for 3 weeks. Intraperitoneal injection of FLX (25 mg/Kg) was performed daily for 14 days in the treatment group. Depressive-like behaviors were assessed, and local field potentials (LFP) from the hippocampus and the PCC were recorded.
Results: FLX effectively reduced depressive-like behaviors in rats with CMS (P≤0.05). Additionally, depression-induced alterations in LFP were observed in the hippocampus and the PCC. Depression reduced the power of delta and theta bands and increased the hippocampal low-gamma band power (P≤0.05). In the PCC, depression increased the power of delta and low-gamma bands and reduced the power of the alpha band (P≤0.05).
Conclusion: FLX reduce depression-like behaviors in the animal model, possibly through affecting electrophysiological activity of the hippocampus and the PCC. |
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| کلیدواژه‌های انگلیسی مقاله |
Depression, Hippocampus, Posterior cingulate cortex, Fluvoxamine, Local field potential recording |
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| نویسندگان مقاله |
| Mahsa Rahimi
School of Biology, Damghan University, Damghan, Iran.
| Iran Goudarzi
School of Biology, Damghan University, Damghan, Iran.
| Kambiz Rohampour
Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
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| نشانی اینترنتی |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-177-2&slc_lang=en&sid=1 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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