|
|
Caspian Journal of Neurological Sciences، جلد ۱۰، شماره ۲، صفحات ۱۱۱-۱۱۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Anxiolytic Effect of Anethum Graveolens Seed Extract Combined With the Antagonist of Estrogen Receptor in Female Rats With Anxiety |
|
| چکیده انگلیسی مقاله |
Background: Anxiety as an important psychological disorder that has affected many people and has made them to spend a lot of money for its treatment.
Objectives: This study aims to assess the anxiolytic effect of the hydro-alcoholic extract of Anethum Graveolens L. seed (AGS) combined with the antagonist of estrogen receptor in female rats with anxiety.
Materials & Methods: In this study, 66 female Wistar rats were divided into eight groups as follow as: Negative control (10 ml/kg saline), positive control (0.6 mg/kg diazepam), five groups of AGS extract (0.1, 1, 10, 100 and 1000 mg/kg) and tamoxifen+AGS extract (10 mg/kg). Anxiety indicators were measured by the elevated plus maze (EPM) test.
Results: The percentage of time spent open arms (%OAT) and percentage open arms entry (%OAE) significantly increased after using 10 mg/Kg dose of AGS extract compared to control group. Tamoxifen could significantly reduce this increase caused by AGS extract on anxiety indices.
Conclusion: Considering the anxiolytic effect of the hydro-alcoholic extract of AGS and the reduction of this effect by the antagonist of estrogen receptor (tamoxifen), it can be concluded that the extract’s anxiolytic effect may be due to interaction with estrogen receptor. |
|
| کلیدواژه‌های انگلیسی مقاله |
Anxiety, Anethum graveolens, Estrogen receptor antagonists |
|
| نویسندگان مقاله |
| Rana Shahabi
Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Mohammad Rostampour
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Behrouz Khakpour
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Edris Mahdavi Fekjur
Trauma Research Institute, Guilan University of Medical Sciences, Rasht, Iran.
| Farshid Saadat
Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
|
|
| نشانی اینترنتی |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-302-2&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|