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Basic and Clinical Neuroscience، جلد ۸، شماره ۱، صفحات ۵۱-۶۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Analgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors |
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| چکیده انگلیسی مقاله |
Introduction: Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as well as allosteric interaction with other membrane-bound receptors like GABAA receptors. This study aimed to examine the role of GABAA receptors in the pain modulating effect of intra-LPGi injection of 17β-estradiol. Methods: To study the antinociceptive effects of 17β-estradiol, cannulation into the LPGi nucleus of male Wistar rats was performed. About 500 nL of drug was administered 15 minutes prior to formalin injection (50 μL of 4%). Then, formalin-induced flexing and licking behaviors were recorded for 60 minutes. For evaluating the role of GABAA receptors in the estradiol-induced pain modulation, 17β-estradiol was administered into the LPGi nucleus 15 minutes after the injection of 25 ng/μL bicuculline (the GABAA receptor antagonist). Then, the formalin-induced responses were recorded. Results: The results of the current study showed that intra-LPGi injection of 17β-estradiol decreased the flexing duration in both phases of formalin test (P< 0.001); but it only attenuated the second phase of licking behavior (P< 0.001). 17β-estradiol attenuated the second phase of formalin test of both behaviors (P< 0.001). Bicuculline prevented the antinociceptive effect of intra-LPGi 17β-estradiol in both first and second phases of formalin-induced responses (P< 0.001). Conclusion: According to the results of this study, the analgesic effect of intra-LPGi 17β-estradiol on the formalin-induced inflammatory pain might be mediated via GABAA receptors. |
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| کلیدواژه‌های انگلیسی مقاله |
17β-Estradiol, GABAA receptor, Pain, Analgesia |
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| نویسندگان مقاله |
رقیه خاکپای | roghaieh khakpay
department of animal science, faculty of natural sciences, university of tabriz, tabriz, iran.
سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)
مریم آزاددار | maryam azaddar
department of animal science, faculty of natural sciences, university of tabriz, tabriz, iran,
سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)
فاطمه خاکپای | fatemeh khakpay
department of biology, faculty of basics sciences, islamic azad university of varamin-pishva, varamin-pishva, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
حمیرا حاتمی نعمتی | homeira hatami nemati
department of animal science, faculty of natural sciences, university of tabriz, tabriz, iran,
سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-797-1&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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