| چکیده انگلیسی مقاله |
Background: Since 2019, the SARS-CoV-2 virus has spread systematically, causing extensive immune responses and significant damage to other organs. This study is a non-randomized, open-labeled, prospective clinical trial, conducted to evaluate the therapeutic potential of plasma exchange (TPE) on critically COVID-19 patients.
Methods: This study is a single-center, clinical trial that was performed at Shahid Beheshti Hospital, Qom University of Medical Sciences, from March to June 2020. A total of 60 patients with a serious or life-threatening infection of COVID-19 were included in the study. Patients in the intervention group (30 patients) received systemic corticosteroids and interferon and TPE were performed for them.
Results: Of 60 patients who were studied, 48% of them died and about 52% were discharged. Mortality was significantly lower in the intervention group than in the control group (20% vs. 77%, respectively). The severity of the disease was significantly lower in the intervention group than in the control group (20% vs. 77%, respectively), as median days of hospitalization and ICU admission were higher in the intervention group than in the control group. No side effects were seen in the intervention group in the first 72 hours after TPE.
Conclusion: Results show that TPE can offer longer lifeline, and low mortality rate in critically COVID-19 patients. Therefore, we recommend that TPE, systemic corticosteroids and, interferon along with other standard treatments, can be used as a part of the treatment protocol for critically COVID-19 patients.
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| نویسندگان مقاله |
| seyed hassan adeli
1Department of Internal Medicine, Faculty of Medicine, Qom University of Medical, Qom, Iran
| Mahmoud Parham
1Department of Internal Medicine, Faculty of Medicine, Qom University of Medical, Qom, Iran
| Akram Asghari
1Department of Internal Medicine, Faculty of Medicine, Qom University of Medical, Qom, Iran
| Reihane Tabaraii
Department of Internal Medicine, Faculty of Medicine, Qom University of Medical, Qom, Iran
| Rasoul Shajari
Department of Internal Medicine, Faculty of Medicine, Qom University of Medical, Qom, Iran
| zahra Abad poor
1Department of Internal Medicine, Faculty of Medicine, Qom University of Medical, Qom, Iran
| sara Afshari
Student research committee, Qom University of Medical Sciences, Qom, Iran
| narges kalhor
Student research committee, Qom University of Medical Sciences, Qom, Iran
| ali ebrazeh
3Department of public health, Faculty of health Qom university of medical sciences, Qom, Iran
| amir jabbari
5Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Sciences, Qom, Iran
| Saeede jafari
4Clinical research development center, Qom University of Medical Sciences, Qom, Iran
| khosro dehghan
4Clinical research development center, Qom University of Medical Sciences, Qom, Iran
| hossein Fazli Sarvestani
4Clinical research development center, Qom University of Medical Sciences, Qom, Iran
| mansoureh shakeri
4Clinical research development center, Qom University of Medical Sciences, Qom, Iran
| Sajjad Ahmadpour
5Patient Safety Research Center Clinical Research Institute Urmia University of Medical Sciences
| Jamshid Vafaeimanesh
Department of Internal Medicine, School of Medicine, Gastroenterology and Hepatology Diseases Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences
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