| چکیده انگلیسی مقاله |
Introduction: Nephrotic Syndrome (NS) is one of the most common kidney diseases in pediatrics. It has impact on thyroid hormones as a result of urine loss of hormone-binding proteins such as transthyretin, thyroxine binding globulin (TBG), and albumin.
Objectives: This study aimed to compare the thyroid hormones profile between children with definite diagnosis of NS and healthy ones.
Patients and Methods: This retrospective case-control study was performed in a pediatric university hospital between Jan 2011 and Dec 2021. Case group consisted of all children with definite diagnosis of nephrotic syndrome who referred to our hospital, and healthy children, who referred to hospital because of routine checkup, enrolled randomly in control group. All variables were compared between case and control groups.
Results: The median age were 5.91±4.14 years and 6.07±3.70 years in control and case group, respectively. TSH and T4 were significantly higher and lower in case group than control, respectively (P-value > 0.05). There is no significant difference between case and control group for Free T4 (1.30±1.95 versus 1.12±0.24 (ng/dL), P-value: 0.558).
Conclusion: Subclinical hypothyroidism is more common in NS children. Actually, it may be due to the albuminuria and loss of TBG in active proteinuria stages.
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| نویسندگان مقاله |
| Mohammad Reza Razavi
Associate professor, Department of Pediatrics, School of Medicine, Qom University of Medical Sciences, Qom, Iran
| Alireza Sharifi
Medical Doctor, Department of Otolaryngology-Head and Neck Surgery, Amir A’lam Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Mohsen Akhavan Sepahi
Associate professor, Department of Pediatrics, School of Medicine, Qom University of Medical Sciences, Qom, Iran
| Mohammad Hossein Afshari
Medical Doctor, Student Research Committee, Qom University of Medical Sciences, Qom, Iran
| Mobina Riahi
Medical Doctor, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
| Mohammad Aghaali
Assistant Professor, School of Medicine, Qom University of Medical Sciences, Qom, Iran
| Sahar Ghaedsharaf
Doctor of Dental Surgery, School of Dentistry, Shahid Beheshti University, Tehran, Iran.
| Mahdi Zarei
Medical Student, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
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