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، جلد ۳، شماره ۱، صفحات ۱۷-۲۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Effects of 8 Weeks Resistance Training on the Expression of MicroRNAs Associated With Adipose Tissue Angiogenesis in Rats on a High-Fat Diet |
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| چکیده انگلیسی مقاله |
Background and Aim: Recent research has shown that microRNAs (miRNAs) can be regarded as new biomarkers for metabolic and angiogenesis-related diseases. This study aimed to investigate the effect of 8 weeks of resistance training on the expression of miRNAs associated with adipose tissue angiogenesis in rats with a high-fat diet.
Materials and Methods: Forty male Wistar rats were randomly divided into four groups (each with 10 rats): normal diet, normal diet+resistance training, high-fat diet, and high-fat diet+resistance training. The resistance training groups performed 5 sessions of resistance training protocol each week for 8 weeks. After one week of familiarity with ladders, in the 2nd week, weights of 30% of body weight were attached to the rats’ tails, which gradually reached about 180% of their body weight by the end of 8 weeks. To evaluate the effect of resistance training and a high-fat diet on miR-221, miR-222, miR-329, and vascular endothelial growth factor (VEGF) variables, sampling of mesenteric adipose tissue was performed immediately after killing the animals.
Results: The levels of miR-221, miR-222, and VEGF in the resistance training group+normal diet and resistance training group+high-fat diet increased significantly compared to the control groups (P=0.001, and P=0.001, respectively). However, no significant difference was observed in any groups regarding miR-329 (P=0.103).
Conclusion: The results showed that resistance training increased microRNAs levels associated with adipose tissue angiogenesis in rats on a high-fat and normal diet. |
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| کلیدواژههای انگلیسی مقاله |
High-fat diet, Angiogenesis, MicroRNAs, Resistance training |
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| نویسندگان مقاله |
| Hamid Sadeghian
Department of Sports Science, Faculty of Literature and Humanities, University of Qom, Qom, Iran
| Marefat Siahkohian
Department of Sports Physiology, Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
| Mohsen Akbarpour Beni
Department of Sports Science, Faculty of Literature and Humanities, University of Qom, Qom, Iran
| Lotfali Bolboli
Department of Sports Physiology, Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
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| نشانی اینترنتی |
http://jvessels.muq.ac.ir/browse.php?a_code=A-10-107-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
vascular physiology |
| نوع مقاله منتشر شده |
پژوهشی |
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