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، جلد ۲، شماره ۴، صفحات ۲۰۱-۲۰۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Effect of an Aerobic Exercise Course on Cardiac Tissue Apoptosis in Adult Male Rats Poisoned With Oxygenated Water |
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| چکیده انگلیسی مقاله |
Background and Aim: Exercise is a strong physiological stimulus that can directly or indirectly affect the process of cardiac apoptosis by affecting some extracellular and intracellular signaling pathways. This study aimed to investigate the effect of aerobic exercise on cardiac tissue apoptosis in rats poisoned with oxygenated water.
Materials and Methods: In this experimental study, 24 male Wistar rats with a weight range of 200-220 g and a mean age of 8-10 weeks were divided into 3 groups, each group containing 8 rats: (1) healthy control (HC), (2) toxicant control (TC), and (3) toxic aerobic exercise (AE). To induce apoptosis, a 9% oxidant, with a large amount of oxygenated water was used by inhalation for 3 hours daily. Twenty-four hours after the last exercise, rats were sacrificed, and their tissue samples were isolated and kept at -80 ° C. Then, the expression of BAX, Caspase 3, and BCL2 genes in cardiac tissue was measured using RT-PCR. Kolmogorov-Smirnov statistical test and one-way analysis of variance with Tukey post hoc test in SPSS software v. 22 were used to analyze the data (P≥0.05).
Results: Exposure to oxygenated water significantly increased BAX (P=0.001) and Caspase 3 (P=0.002) and significantly decreased BCL2 gene expression (P=0.001) in cardiac tissue. While aerobic exercise decreased levels of BAX (P=0.001) and Caspase 3 (P=0.001) and increased BCL2 (P=0.000) in the cardiac tissue of rats poisoned with oxygenated water.
Conclusion: It seems that a period of aerobic exercise with significant changes in the expression of genes involved in oxygenated apoptosis can be used as a complementary therapy and other methods to modulate the apoptosis of cardiac tissue. |
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| کلیدواژه‌های انگلیسی مقاله |
Exercise, Apoptosis, Cardiac, Hydrogen peroxide |
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| نویسندگان مقاله |
سید مصطفی رضایی | Seyed Mostafa Rezaei
Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
بهرام عابدی | Bahram Abedi
Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
حسین فتح الهی | Hossein Fatolahi
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
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| نشانی اینترنتی |
http://jvessels.muq.ac.ir/browse.php?a_code=A-10-97-1&slc_lang=fa&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
cardiovascular diseases |
| نوع مقاله منتشر شده |
پژوهشی |
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