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، جلد ۲، شماره ۴، صفحات ۲۰۹-۲۱۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Effect of a HIIT Training Course on the Expression of PGC-1α, SIRT1, and SIRT3 Genes in the Cardiac Tissue of Elderly Female Rats |
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| چکیده انگلیسی مقاله |
Background and Aim: Exercise improves the function of mitochondrial proteins and enzymes in old age. This study aimed to investigate the effect of a high-intensity interval training (HIIT) training course on the expression of PGC-1α, SIRT1, and SIRT3 genes in the cardiac tissue of elderly female rats.
Materials and Methods: In this experimental study, 14 female Sprague-Dawley rats with a mean age of 16-18 months and a weight range of 280-320 g were randomly divided into 2 groups of 7, including the control group and the HIIT training group. The experimental group performed HIIT training for 8 weeks and 5 days a week with an intensity of 85%-110% VO2max. Forty-eight hours after the last training session, rats were anesthetized by intraperitoneal injection of ketamine and xylazine, and the target tissue was immediately removed for examination. Shapiro-Wilk statistical test and one-way analysis of variance in SPSS software v. 22 analyzed the findings (P≥0.05).
Results: The results showed that the expression of PGC-1α, SIRT1, and SIRT3 genes increased in the cardiac tissue of the experimental group compared to the control group after 8 weeks of HIIT training, but this increase was not significant (P≤0.05).
Conclusion: It seems that in elderly conditions, exercise from pathways other than PGC-1α improves mitochondrial function. However, further research is needed on the effect of HIIT exercise on the expression of these genes in cardiac tissue. |
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| کلیدواژههای انگلیسی مقاله |
HIIT training, Organelle Biogenesis, Aged, Heart |
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| نویسندگان مقاله |
| Khadijeh Hassanpour
Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
| Bahram Abedi
Department of Physical Education,Tehran North Branch, Islamic Azad University.
| Lida Moradi
Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran.
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| نشانی اینترنتی |
http://jvessels.muq.ac.ir/browse.php?a_code=A-10-100-1&slc_lang=fa&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
cardiovascular diseases |
| نوع مقاله منتشر شده |
پژوهشی |
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