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، جلد ۲، شماره ۲، صفحات ۶۳-۶۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Plasma Cell-free DNA Levels in Children With Acute Lymphoblastic Leukemia |
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| چکیده انگلیسی مقاله |
Background and Aim: Plasma levels of cell-free DNA (cfDNA) are elevated in various clinical conditions, including cancer, myocardial infarction, autoimmune disease, and pregnancy-associated complications. The aim of this study was to determine the level of cfDNA to assess the potential of cfDNA as a biomarker for screening and diagnosis and also its effectiveness in the treatment of patients with acute lymphoblastic leukemia (ALL).
Materials and Methods: Overall, 40 individuals (20 healthy volunteers and 20 patients with ALL) were examined. For quantitative analysis of cfDNA, plasma purified DNA was subjected to real-time PCR amplification of the beta-globin gene. Quantification of cfDNA levels was performed at the time of diagnosis and after treatment with a common protocol.
Results: At diagnosis, in all samples, plasma levels of cfDNA were significantly elevated compared to those of healthy controls after treatment. The high levels of cfDNA decreased and returned to normal after treatment.
Conclusion: Data showed that despite the significant cfDNA concentration increment in patients than the control group, its detection and treatment potential should be more studied: however, it still can be a useful marker for screening of diseases, such as hematological neoplasms. |
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| کلیدواژههای انگلیسی مقاله |
Cell free, Nucleic acids, Precusor cell, Lymphoblastic Leukemia, Lymphoma, Biomakers |
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| نویسندگان مقاله |
| Alihossein Saberi
Department of Medical genetic, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
| Asghar Elahi
Department of Medical Technology, Faculty of Paramedicine, Qom University of Medical Sciences, Qom, Iran.
| Mohammad Taha Jalali
Department of Medical Technology, Faculty of Paramedicine ,Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
| Seyed Mahmoud Latif
Department of Medical genetic, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
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| نشانی اینترنتی |
http://jvessels.muq.ac.ir/browse.php?a_code=A-10-54-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
hematology |
| نوع مقاله منتشر شده |
پژوهشی |
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