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، جلد ۲، شماره ۱، صفحات ۳۶-۳۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
A Randomized Controlled Trial of Neuroprotective Effects of N-Acetyl-Cysteine in Patients with Acute Ischemic Stroke |
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| چکیده انگلیسی مقاله |
Background and Aim: To investigate the neuroprotective effects of NAC (N-Acetyl-Cysteine) in patients with AIS (Acute Ischemic Stroke).
Materials and Methods: The study was a single blind placebo controlled trial. 62 patients were enrolled in the study, 31 patients in each arm. NAC was infused for the intervention group with doses of 100 mg/kg stat on admission then 10 mg/kg/hour for 10 hours in addition to standard treatment. The control group only received standard treatment. The blood sample for measuring MMP-9 (Matrix Metalloproteinase 9) was collected from both groups before and 24 hours after receiving NAC. NIHSS (National Institutes of Health Stroke Scale) was calculated for both groups before therapy, 24 hours, 2 weeks, 1 month and 3 months after therapy.
Results: Mean NIHSS in the intervention and control groups were 6.87±4.15 and 8.11±4.12 (p-value = 0.231) on admission, 4.52±3.82 and 5.87±4.36 (p-value = 0.193)24 hours after admission, 3.06±2.74and 4.93±4.69 (p-value = 0.061)2 weeks later, 2.39±2.41and 3.66±4.98 (p-value = 0.2 25) one month later, and, 1.07±2.12and 2.36±2.28 (p-value = 0.511) 3 months later respectively, which were not statistically significant. Also, the relationship between MMP9 and NIHSS was evaluated using Pearson correlation coefficient. There was no significant correlation between MMP9 changes and neurological deficits in any of the time intervals. In both intervention and control groups, the amount of MMP9 24 hours after injection was decreased dramatically (p-value = 0.000) and showed that MMP9 reduction was not dependent on NAC injection.
Conclusion: NAC injection did not show clinical and laboratory benefits in patients with AIS in addition to standard therapy. |
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| کلیدواژههای انگلیسی مقاله |
Acetylcysteine, Ischemia, Stroke |
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| نویسندگان مقاله |
| Rezan Ashayeri Ahmadabad
Neurologist, Iran University of Medical Sciences, Firoozgar Hospital
| Zahra Mirzaasgari
Assistant Professor in Neurology, Iran University of Medical Sciences, Firoozgar Hospital
| Amir Kiaani
Associate Professor of Toxicology, Kermanshah University of Medical Sciences, School of Pharmacology
| Parnian Kheir khah
General physician, Iran University of Medical Sciences
| Melina Hosseiny
Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences.
| Ali Sohrabi
Gastroenterologist, Iran University of Medical Sciences, Firoozgar Hospital
| Ali Rafati
General physician, Iran University of Medical Sciences
| Maryam Bahadori
General physician, Iran University of Medical Sciences
| Masoud Mehrpour
Associate Professor in Neurology, Iran University of medical sciences, Firoozgar Hospital
| Azadeh Eshraghi
Assistant professor in Clinical Pharmacy, Iran University of medical sciences, Faculty of Pharmacy
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| نشانی اینترنتی |
http://jvessels.muq.ac.ir/browse.php?a_code=A-10-1-38&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
stroke |
| نوع مقاله منتشر شده |
پژوهشی |
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