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، جلد ۲، شماره ۱، صفحات ۳۹-۳۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Vitamin D Supplementation in Acute Ischemic Stroke |
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| چکیده انگلیسی مقاله |
Background and Aim: Vitamin D deficiency was associated with an increased risk of stroke. Clinical studies have reported improved neurological outcomes in patients who were taking vitamin D supplements. This study proposed to investigate the effect of intramuscular vitamin D treatment in patients with acute ischemic stroke on neurological outcomes, and inflammatory marker levels.
Materials and Methods: seventy-three patients with AIS included in the study and were allocated randomly into single dose 300000 UI an intramuscular vitamin D group or a control group. Serum vitamin D concentration, IL-6 and tumor necrosis factor-α (TNF-α) levels, as primary outcomes, and the Modified Ranking Scale (MRS), the National Institute of Health Stroke Scale (NIHSS) and the Mini-Mental State Examination (MMSE), as secondary outcomes, were measured at the base line and at the end of the study. (6 weeks)
Results: Eventually, 24 patients with AIS completed the intervention study. A single dose of 300000 UI increased vitamin D level and there were reverse correlation between level of serum vitamin D and NIHSS and TNF-α after taking vitamin D. However, no statistically significant effect of vitamin D on the TNF-α and IL-6 levels and on neurological score as compare to control.
Conclusion: Further randomized controlled trials are urgently needed to prove whether vitamin D supplementation reduces the incidence of strokes, improves the outcome of post-stroke patients, and elucidate the relationship between the timing of treatment with calcitriol and neuroprotection. |
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| کلیدواژه‌های انگلیسی مقاله |
Ischemic stroke, Inflammation, Neurological deficit, Vitamin D |
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| نویسندگان مقاله |
| Leila Simani
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Mahtab Ramezani
Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Bahareh Fazeli
Departmeny of Clinical Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
| Mehrdad Roozbeh
Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
http://jvessels.muq.ac.ir/browse.php?a_code=A-10-1-41&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
stroke |
| نوع مقاله منتشر شده |
پژوهشی |
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