|
|
، جلد ۱۸، شماره ۱، صفحات ۳۳-۴۲
|
|
|
| عنوان فارسی |
اثرات کاهش دهنده آلفا توکوفرول بر سمیت ناشی از سیتارابین در غده بزاقی پاروتید خرگوش: یک مطالعه بافت شناسی و ایمونوهیستوشیمی |
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Attenuating Effects of α-tocopherol on Cytarabine-Induced Toxicity in Parotid Salivary Gland of Rabbits: A Histological and Immunohistochemical Study |
|
| چکیده انگلیسی مقاله |
Background: Cytarabine is considered a cornerstone of treating acute leukemia. Xerostomia is among the adverse effects that can dictate treatment cessation or the use of some agents that decrease its cytotoxic effects.
Objectives: This study aims to identify the histological effects of cytarabine on the rabbits’ parotid gland and to assess the ameliorating α–tocopherol impact on these effects.
Methods: The study rabbits were separated into 4 groups. Group A (control) was given 1 mL of intraperitoneal (IP) injection of normal saline/day for 10 days. Group B received α-tocopherol (800 IU) by gavage for 10 days. Group C received cytarabine (60 mg/kg/d) IP for 10 days. Group D received α-tocopherol (800 IU) by gavage before injection of cytarabine (60 mg/kg) at the same time for 10 days. The rabbits were euthanized, and tissue preparation for analyzing microscopically and immunohistochemically for B-cell lymphoma 2 (Bcl-2) and tumor-necrosis-factor (TNF)-α was achieved.
Results: Microscopically, group B’s parotid salivary gland sections revealed increased thickness of connective tissue of the trabeculae, degeneration, and necrosis of serous acini cells with aggregation of inflammatory cells. In contrast to the histopathological alteration of the glands in group C, which is characterized by intact serous acini, intercalated duct, and normal thickness of trabeculae, in the cytarabine group, TNF-α immunohistochemical expression was of grade 3 and in the cytarabine with α-tocopherol group was of grade 1. The Bcl-2 immunohistochemical expression in the cytarabine group was of grade 0, and in the cytarabine with α-tocopherol group was of grade 1.
Conclusion: α-Tocopherol decreases cytarabine toxicity in the rabbits’ parotid salivary glands.
|
|
| کلیدواژه‌های انگلیسی مقاله |
α-tocopherol,Bcl-2,Cytarabine,Parotid salivary gland,TNF-α |
|
| نویسندگان مقاله |
Saif Al-Jammas |
Department of Basic Dental Sciences, College of Dentistry, University of Mosul, Mosul, Iraq.
Luma Ibrahim Khalel Al-Allaf |
Department of Anatomy, College of Medicine, University of Mosul, Mosul, Iraq.
Mohammed Ghassan Saeed |
Department of Pathology and Poultry Diseases, College of Veterinary Medicine. University of Mosul, Mosul, Iraq.
|
|
| نشانی اینترنتی |
https://ijvm.ut.ac.ir/article_93260_6a624ee3d39fe76303728e52fa2cb307.pdf |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|