| چکیده انگلیسی مقاله |
Background: Over the past decade, following the discovery that developing brain of immature animals was affected by anesthetic agents, the safety of general anesthesia in early life of human has been questioned.
Aim & Objective: We investigated the association between early exposure to general anesthesia and Autism development.
Material & Methods: This case control study was conducted at pediatric psychology clinic of an academic hospital affiliated with Guilan University of Medical Sciences (GUMS) from December 2021 to April 2024. Firstly, the responsible resident of anesthesiology sorted out the Autism cases files that was diagnosed based on DSM-5 criteria. Then a questionnaire was filled out through a telephone interview. The data from 540 children were analyzed and the frequency distribution of general anesthesia exposure was compared between Autism cases and controls.
Results: Comparing two groups a significant difference was observed in terms of birth status (term/pre-term) (P=0.031), history of receiving anesthesia under 4 years (P=0.039), age of receiving anesthesia (p=0.021) and Type of surgery requiring anesthesia (elective/emergency) (P=0.022). Multivariate analysis using logistic regression showed that only the variable of receiving anesthesia has a significant role in the incidence of autism behavioral disorders (P=0.043). So that children who had a history of receiving anesthesia were 1.47 times more likely to have autism.
Conclusion: It was revealed that early exposure to GA might be a risk factor for later developing of Autism. Further prospective well-planned studies are needed to confirm these findings. |
| نویسندگان مقاله |
| Abbas Sedighinejad
Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
| Maryam Kousha
Department of Psychiatry, School of Medicine, Shafa Hospital, Guilan, University of Medical Sciences, Rasht, Iran.
| Soheil Soltanipour
Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Erfan Vakili
Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
| Novin Naderi
Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
| Gelareh Biazar
Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
| Mahin Tayefeh Ashrafiyeh
Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
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