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Caspian Journal of Neurological Sciences، جلد ۱۰، شماره ۴، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Role of Olive Oil and Olive Derived Extracts in Alzheimer’s Disease: A Systematic Review of Experimental Studies in Mice and Worm Models |
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| چکیده انگلیسی مقاله |
Background: Alzheimer's Disease (AD) and its incidence is anticipated to increase, especially in Indonesia. Despite lacking a cure, extra-virgin olive oil, abundant in neuroprotective compounds, offers potential in delaying cognitive decline by combating oxidative stress in the aging brain. Research indicates its capacity to bolster long-term cognitive function and memory.
Objective: Examine the olive oil and its derivatives' impact on AD through an comprehensive analysis of experimental studies in mouse and worm models.
Methods: Thirteen relevant articles were selected from the initial pool based on specific inclusion criteria. Data were extracted regarding study design, intervention types, model species used, cognitive outcomes, and findings. The reliability of the selected studies was ensured by evaluating their methodological quality and risk of bias.
Results: Our systematic review of 13 selected experimental studies involving mice and worm models provides insights into the potential impact of olive oil and extracts derived from it on AD. Findings suggest that these interventions may exhibit neuroprotective properties, positively influencing cognitive function and mitigating AD-related outcomes in the experimental models studied.
Conclusion: Findings from experimental studies on mice and worm models suggest olive oil and its extracts may confer neuroprotective benefits and positively influence cognitive function in AD contexts. Nonetheless, further research, especially involving human subjects, is essential to validate these findings and explore their practical implications in AD prevention and management. |
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| کلیدواژه‌های انگلیسی مقاله |
Experimental Animal Models, Alzheimer Disease, Dementia, Olive Oil, Systematic Review |
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| نویسندگان مقاله |
| Alexander Tikara Sugondo
Indonesian Medical Association (IDI) Surabaya Chapter, Indonesia.
| Qorina Nadya Salfi
Indonesian Medical Association (IDI) Surabaya Chapter, Indonesia.
| Maura Tuzzahrah Ramadhani
Indonesian Medical Association (IDI) Surabaya Chapter, Indonesia.
| Vania Ayu Puspamaniar
Indonesian Medical Association (IDI) Surabaya Chapter, Indonesia.
| Abdulloh Machin
Departement of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
| Yudha Haryono
Departement of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
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| نشانی اینترنتی |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-471-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
مروری |
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