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، جلد ۱۸، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective Effect of Carvacrol Against Acute Liver Damage and Encephalopathy Induced by Thioacetamide |
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| چکیده انگلیسی مقاله |
Background: Cancer occurs in 83% of liver diseases. Other risk factors for liver cancer include viral hepatitis, alcohol consumption, industrial chemicals, and a number of toxins. Another major disease that occurs following liver damage is hepatic encephalopathy. This condition arises primarily due to increased blood ammonia levels. Carvacrol, with antioxidant properties, reduces oxidative stress on the liver. The aim of this study was to investigate the effect of carvacrol on the improvement of hepatic encephalopathy in rats.
Methods: In this experimental study, 60 male Wistar rats were randomly divided into six groups of 10 each. Liver damage and induction of oxidative stress were caused in the rats by administering thioacetamide (100 mg/kg/day) intraperitoneally for three consecutive days. Carvacrol was administered by gavage at 25, 50, or 100 mg/kg/day after thioacetamide treatment. We investigated the biomarkers of liver damage in the blood, such as alanine transaminase, lactate dehydrogenase, total protein, and bilirubin. We also assessed the effect of oxidative stress, as the key inducer of hepatic encephalopathy, on the liver by measuring the lipid peroxidation, antioxidants, reactive oxygen species, glutathione reserves, and ammonium levels in the serum and brain.
Results: Thioacetamide significantly increased the biochemical markers in the rat sera, reflecting ammonium release and the development of oxidative stress (P<0.05). Conversely, the various doses of carvacrol significantly reduced the levels of biomarkers that are indicative of liver damage (P<0.05).
Conclusion: The study findings provided experimental evidence in favor of the therapeutic effects of carvacrol and against liver injury induced by thioacetamide, leading to encephalopathy. |
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| کلیدواژه‌های انگلیسی مقاله |
Ammonium, Carvacrol, Hepatic encephalopathy, Oxidative stress, Thioacetamide liver damage |
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| نویسندگان مقاله |
| Anahita Esmaeili
Pharmacy Student, Student Research Committee, Lorestan University of Medical Sciences. Khoram-Abad, Iran.
| Peyman Astaraki
Department of Internal Medicine, School of Medicine, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoram-Abad, Iran.
| Mohammad Jamalian
Department of Forensic Medicine, School of Medicine, Valiasr Hospital, Arak University of Medical Sciences, Arak, Iran.
| Hamidreza Mohammadi
Department of Toxicology, Faculty of Pharmacy, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khoram-Abad, Iran.
| Naser Reza Ziyaeenia
Department of Health Education, School of Medicine, Lorestan University of Medical Sciences, Khoram-Abad, Iran
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1209-1&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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