|
|
، جلد ۱۸، شماره ۳، صفحات ۰-۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Anti-Colon Cancer Activity of Nano-synthetic Quinolone: In vivo and In vitro Study |
|
| چکیده انگلیسی مقاله |
Background: Colon cancer is one of the most prevalent malignancies in both men and women. This study investigated the anticancer efficacy of a new synthetic form of quinolone nanoparticles (QNPs) against colon cancer cells. As an experimental model, we investigated methods to prevent the development of colon cancer in adult male albino rats induced by 1,2-dimethylhydrazine (DMH).
Methods: Forty adult male rats (weighing 150-200 g) were randomly assigned to four groups of ten as follows:
Group 1: Normal rats considered the reference group.
Group 2: Normal rats treated intraperitoneally with 100 μg/kg/day of quinolone.
Group 3: Rats with induced colon cancer by DMH.
Group 4: Rats with colon cancer, as the experimental model, and administered QNPs at 100 μg/kg/day for 6 weeks.
Results: The results showed that QNPs significantly improved the treatment of induced colon cancer in rats. This finding was supported by significant increases in CD4, colon SOD, and GPx activity, as well as in GSH and CAT levels. Further discoveries included a significant decline in the serum values of CEA, CA19-9, AFP, TNF-α, IL1β, ALT, AST, urea, creatinine, cholesterol, triglycerides, colon DNA damage, MDA, and NO. The histopathological results demonstrated the therapeutic potential of QNPs, which were successful in halting the development of colon cancer in an experimental animal model.
Conclusions: The findings of the current study demonstrated that QNPs were able to prevent colon cancer in rats by enhancing their immune system, lowering inflammatory markers, and improving damaged oxidative stress tolerance. |
|
| کلیدواژه‌های انگلیسی مقاله |
Anticancer, Colon cancer, Dimethylhydrazine (DMH), Nanoparticles, Quinolone |
|
| نویسندگان مقاله |
| Asmaa Mohammed Attya
Zoology Dept, Faculty of Science, Al-Azhar University, Assuit, Egypt
| Abdelbaset M.A. Abdelreheem
Zoology Dept, Faculty of Science, Al-Azhar University, Assuit, Egypt
| Doaa Galal El-Sahra
Modern University for Technology and Information, Cairo, Egypt.
| Mohammed A. Abdel-Aal
Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt.
| Mahmoud Ashry
Zoology Dept, Faculty of Science, Al-Azhar University, Assuit, Egypt
|
|
| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1122-4&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|