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Basic and Clinical Neuroscience، جلد ۸، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Correlation Between Cannabidiol-Induced Reduction of Infarct Volume and Inflammatory Factors Expression in Ischemic Stroke Model |
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| چکیده انگلیسی مقاله |
Introduction: Recent studies demonstrated that cannabidiol had neuroprotective property. Thereis some evidence about effective role of cannabidiol in reducing ischemic damages. It has been reported that infarct size is influenced by various factors after MCAO, including inflammatory factors. The aim of the present study was to evaluate the effect of cannabidiol on infarction volume and correlation of infarct size with tumor necrosis factor receptor 1 (TNFR1), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) expression. Methods: Using stereotaxic surgery, guide cannula was implanted in the right lateral ventricle. Cannabidiol (50, 100, and 200 ng) was injected through ntracerebroventricular (i.c.v.) route for 5 consecutive days . Then, the rats underwent 60 minutes of right middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the infarct volume in total, cortex, piriform cortex-amygdala (Pir-Amy), and striatum areas of hemisphere were assessed. The expression of inflammatory factors such as TNFR1 and NF-кB in these regions were also studied. Results: The present results indicate that in the MCAO-induced cerebral ischemia, administration of cannabidiol (100 and 200 ng) causes a significant reduction in infarction volume in comparison with the vehicle group. Also, there were significant correlations between decrease of regional infarct volume and TNFR1/NF-кB expression. Conclusion: The results of this study indicate that cannabidiol reduced cerebral infarction possibly through diminishing TNFR1/NF-кB-induced neurotoxicity in transient focal cerebral ischemia. |
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| کلیدواژه‌های انگلیسی مقاله |
Cannabidiol, Cerebral ischemia, Infarction, TNFR1, NF- кB. |
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| نویسندگان مقاله |
محمدرضا بیگدلی | mohammad reza bigdeli
department of physiology, biological science faculty, shahid beheshti university, daneshjoo blv, evin, tehran, iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
سپیده خاکسار | sepideh khaksar
department of physiology, biological science faculty, shahid beheshti university, daneshjoo blv, evin, tehran, iran
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-324-2&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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