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عنوان انگلیسی A Case Report of Isovaleric Acidemia without Acidosis
چکیده انگلیسی مقاله The deficiency of isovaleryl-CoA dehydrogenase leads to an inborn recessive error of leucine metabolism named isovaleric acidemia (IVA). Its presentation may be either in the neonatal period as an acute episode of metabolic acidosis or later as a “chronic intermittent form”. Normal development is promoted by early diagnosis and treatment with a protein restricted diet and supplementation with carnitine and glycine. The present case was a 35-day-old boy admitted with seizure whose initial screening test was in favor of organic acidemia of the isovaric acidemia (Ammonia: 200 µmol/L). As the venous blood gas (VBG) analysis revealed no acidosis, newborn metabolic screening was repeated. Typical laboratory findings and elevated levels of C5 and C5/C2 confirmed isovaleric acidemia again. As the above patient had no acidosis while the other tests including laboratory and genetic analysis were in favor of IVA, he considered to be a rare case.
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نویسندگان مقاله | Mahtab Ordooei
Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AND Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Razieh Fallah
Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AND Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Maryam Saeida-Ardekani
Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Fahimeh Soheilipour
Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran


| Mahdieh Yavari
Dr. Mazaheri’s Medical Genetics lab, Yazd, Iran. AND Division of Genetics, Department of Cell, Molecular Biology and Microbiology, Faculty of Science and Biotechnology, University of Isfahan, Isfahan, Iran.


| Mahta Mazaheri
Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AND Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.



نشانی اینترنتی https://crcp.tums.ac.ir/index.php/crcp/article/view/829
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