Journal of Holistic Nursing and Midwifery، جلد ۳۵، شماره ۱، صفحات ۰-۰

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عنوان انگلیسی Comparison of vitamin D and zinc dietary intake and serum levels in women with diminished ovarian reserve compared to normal population: A case-control study
چکیده انگلیسی مقاله Introduction: To date, limited studies have been performed to evaluate the relationship between serum levels of vitamin D and zinc and ovarian reserve, which presents very contradictory results, and therefore this issue remains unsettled.
Objective: The purpose of this case-control study was to compare vitamin D and zinc dietary intake and serum levels in women with diminished ovarian reserve (DOR) compared to normal population.

Materials and Methods: The study case-control study was performed on women referred to a fertility clinic in Iran by convenience sampling. The case group (n=55) included women with DOR (anti-Müllerian hormone (AMH) < 1ng/ml and AFC count< 10 in sonography at 3-10 days of menstrual cycle). The control group (n=44) was women with normal ovarian reserve markers. Dietary intake using a food frequency questionnaire (FFQ) and serum concentration of zinc and vitamin D were determined for each participant. The obtained data were analyzed using the t-test or χ2. BMI and age were adjusted by covariance analysis. Significance level was considered P≤0.05.
Results: The mean age of the participants was 33.4± 26.58 and 32.4 ± 31.16 years in the case and control groups, respectively. The mean BMI of participants was 27.15±3.97 in the case group and 26.35±4.23 in the and control groups.The results of this study have shown that, after BMI and age adjustment, dietary intake (6.98±0.57 vs. 4.02±1.09; P=0.05) and serum vitamin D (20.91±5.23 vs. 17.12±8.73; P=0.05) levels were significantly higher in the control group compared to the DOR population. The adjusted effect size for age and BMI for Dietary intake of vitamin D was 0.86 and for Serum vitamin D levels was 0.52. Dietary intake (8.75±2.55 vs. 10.68±4.75) and serum zinc (87.09±10.02 vs. 87.09±10.02) levels did not differ significantly in the control group compared to the DOR population, after BMI and age adjustment.

Conclusion: In conclusion, the results of this case-control study in DOR support a possible favorable relation between dietary intake and serum vitamin D levels and ovarian reserve and this relationship is independent of age and BMI. Further clinical studies, in particular RCTs, are needed to clarify the potential positive effects of vitamin D on ovarian reserve in DOR women.

کلیدواژه‌های انگلیسی مقاله Ovarian reserve, zinc, vitamin D, dietary intake

نویسندگان مقاله | Shahintaj Aramesh
Department of Gynecology and Obstetrics, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran


| Fatemeh Azaraksh
Department of Gynecology and Obstetrics, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran


| Ramin Jannesar
Department of Pathology, School of Allied Medical Sciences, Yasuj University of Medical Sciences, Yasuj, Iran


| Marcello Iriti
Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20133, Milan, Italy


| Fatemeh Bazarganipour
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran



نشانی اینترنتی http://hnmj.gums.ac.ir/browse.php?a_code=A-10-2015-2&slc_lang=en&sid=1
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