| چکیده انگلیسی مقاله |
Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease affecting the central nervous system (CNS). While most cases are sporadic, familial MS (FMS) constitutes approximately 12.6% of the MS population and is characterized by affected family members. This study aims to investigate the difference between clinical and radiological findings of patients with FMS and sporadic MS (SMS) living in Guilan Province, Iran.
Materials & Methods: In this cross-sectional study, by evaluating their medical records, we examined 113 patients with SMS and 79 patients with FMS who registered in the nationwide MS registry of Iran (NMSRI)-Guilan. The radiologic data were analyzed using OsiriX software, version 12.0.
Results: Compared to the FMS group, the SMS group showed significantly higher age at onset (31.48±9.55 vs 28.92±9.46, P=0.034), higher occurrence of diplopia (29.2% vs 16.4%, P=0.042), higher expanded disability status scale (EDSS) score (2.20±2.61 vs 1.09±2.08, P=0.002), more lesions (31.59±25.36 vs 22.83±17.17, P=0.017), higher frequency of lesions in the periventricular region (98.2% vs 89.8%, P=0.017) and the lower average size of the smallest lesions (4.65±2.57 vs 8.12±8.58, P<0.001). EDSS score showed significant associations with type of MS (SMS or FMS) (β=0.78, P=0.016), onset age (β=0.09, P<0.001) and disease duration (β=0.13, P=0.001).
Conclusion: FMS differs from SMS with an earlier onset, predominantly relapsing-remitting phenotype, lower diplopia incidence, lower EDSS scores, fewer periventricular lesions and larger smallest lesions. |
| نویسندگان مقاله |
| Kamal AmirAshjei Asalemi
Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Alia Saberi
Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Amirreza Ghayeghran
Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Sima Fallah Arzpeyma
Department of Radiology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
| Sharareh Eskandarieh
Neuroscience Institute, Multiple Sclerosis Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
| Mohammad Ali Sahraian
Neuroscience Institute, Multiple Sclerosis Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
| Hamidreza Hatamian
Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Kasra Sarlak
Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Negin Ashoori
Department of Neurology, Faculty of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
| Nima Broomand Lomer
Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
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