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، جلد ۱۹، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Hormonal, Inflammatory Modulatory and Antioxidant Effects of Glycyrrhiza glabra L Extract in Polycystic Ovary Syndrome-Modeled Rats |
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| چکیده انگلیسی مقاله |
Abstract
One of the most prevalent metabolic conditions affecting women in their reproductive years that cause infertility or subfertility is Polycystic Ovary Syndrome, or PCOS. This was a pilot study to see whether Glycyrrhiza glabra L. aqueous extract (GAE) could prevent or treat PCOS in rats that had been given Estradiol®. Following acclimation, four groups of adult female Wistar albino rats weighing between 160 and 200 grams each were randomly assigned; Normal rats were used in the first group as a control, In the second group, normal rats were given 100 mg/kg of Glycyrrhiza glabra L orally for a period of six weeks, Third group: animals modelled by Polycystic Ovary Syndrome that were not treated served as a positive control, and lastly, Glycyrrhiza glabra L was administered to a group of animals modeled for PCOS for a period of six weeks. The obtained results showed that the PCOS caused by Estradiol® was significantly restored by Glycyrrhiza glabra L extracts; The results demonstrated a considerable reduction in serum levels of FSH, LH, PRL, testosterone, E2, TNF-α, IL-1β, IL-4, IL-6, and IL-10, along with a slight increase in insulin and progesterone levels, indicating that Glycyrrhiza glabra L extract significantly controlled PCOS deteriorations. Comparably, a noteworthy improvement in the oxidative status was noted; ovarian SOD, GPx, CAT, and GSH levels were significantly raised, accompanied by a notable decrease in MDA and NO levels. Additionally, urea, creatinine, cholesterol, triglycerides, and ALAT and ASAT activities were significantly reduced, and GAE showed nephro-hepatoprotective and anti-atherogenic capabilities; these results were in line with the comparable values of the healthy group. Histological analysis corroborated these results. In summary, GAE's phytochemicals, antioxidant, and anti-inflammatory qualities, along with its capacity to cause folliculogenesis, allowed it to effectively alleviate the effects of Estradiol®-induced polycystic ovary.
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| کلیدواژه‌های انگلیسی مقاله |
Polycystic Ovary Syndrome, Estradiol®, Glycyrrhiza glabra L, Anti-inflammatory, Antioxidant, Rat |
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| نویسندگان مقاله |
| Walaa A Kandeel
PhD in Nutrition and Food Science, Faculty of Specific Education, Assiut University, Assuit, Egypt
| Seham A Farag
PhD in Nutrition and Food Science, Faculty of Specific Education, Assiut University, Assuit, Egypt
| Hend M Ali
PhD in Nutrition and Food Science, Faculty of Specific Education, Assiut University, Assuit, Egypt
| Mahmoud Ashry
PhD in Zoology, Zoology Department, Faculty of Science, Al-Azhar University, Assuit, Egypt
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1122-5&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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