Background and Purpose: Despite the availability of vaccines, measles has remained a significant health threat, with recent global surges in cases. This study focused on factors influencing measles vaccine compliance in barangay C, Northern Mindanao, Philippines. It aimed to identify barriers to compliance and assess differences in compliance levels based on demographic factors like age, decision-maker, and educational attainment. 
Materials and Methods: This study utilized a non-experimental quantitative descriptive design to examine factors influencing measles vaccination compliance among residents of barangay C. The study data were collected using a structured survey questionnaire that served as the instrument designed to measure compliance across psychosocial factors and behavioral-specific cognitions. The sample comprised 132 respondents aged 18 to 59 who met the inclusion criteria. Statistical analyses, including the t-test and ANOVA/F-tests, were employed to evaluate significant differences in vaccination compliance when grouped by age, family decision-makers, and educational attainment. Results highlighted group-specific variations in compliance, emphasizing psychosocial and behavioral determinants, with significance levels determined at P<0.05.
Results: Younger adults showed higher compliance with psychosocial factors (mean: 3.50) compared to middle-aged adults (mean: 3.42), while middle-aged adults exhibited higher compliance with behavioral-specific cognitions (mean: 3.42). However, t-test revealed no significant differences in compliance levels based on age (P=0.834 for psychosocial factors and P=0.675 for behavioral-specific cognitions). Among decision-makers, mothers exhibited the highest compliance with psychosocial factors (mean: 3.57), and this difference was statistically significant (P=0.029). No significant differences were found in compliance levels based on educational attainment, with P=0.714 for psychosocial factors and P=0.863 for behavioral-specific cognitions.
Conclusion: No significant differences were found based on age and educational attainment; the study underscores the importance of decision-makers, particularly mothers, in shaping vaccination behaviors. These insights suggest that vaccination programs could benefit from improving psychosocial factors and addressing the specific needs of decision-makers, thereby promoting higher compliance with vaccination recommendations.