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Pharmaceutical and Biomedical Research، جلد ۱۱، شماره ۱، صفحات ۴۱-۴۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice |
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| چکیده انگلیسی مقاله |
Background: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions.
Objectives: This study aims to evaluate the A. sinkatana plant’s anti-psoriatic properties.
Methods: The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant. So, the effects of 0.1% and 0.2% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version 20. At P<0.05, differences were deemed significant. A minimum of three replicates were used in each duplicate experiment. For all values, Mean±SD was used.
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% Aloe extract (A.E), 0.1% A.E, and dexamethasone 86%, 84%, and 68%, respectively. Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups’ psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract. This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis. |
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| کلیدواژه‌های انگلیسی مقاله |
Aloe sinkatana, Dermatitis, Extracts, Imiquimod (IMQ), Psoriasis area and severity index (PASI), Mice |
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| نویسندگان مقاله |
| Azza Dawoud Hussien Dawoud
Department of Drug Formulation, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan.
| Mohammed Abdalbagi
Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1362-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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