|
|
Journal of Pediatrics Review، جلد ۱۳، شماره ۲، صفحات ۱۲۵-۱۳۲
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Examining the Clinical Insights Into the Diagnosis of Systemic Lupus Erythematosus in a 7-year-old Patient: A Case Report and Literature Review |
|
| چکیده انگلیسی مقاله |
Background: The complement system is involved in the pathogenesis of systemic lupus erythematosus (SLE) through its role in immune complex clearance, regulation of inflammation, and tissue damage. Dysregulation of the complement system has been implicated in the development and progression of SLE, making it a potential target for therapeutic interventions.
Case Presentation: This study presents a case study involving a 7-year-old Baloch patient initially diagnosed with juvenile idiopathic arthritis (JRA) at the age of 2 years. Subsequently, following the emergence of pulmonary symptoms and persistent rheumatologic manifestations, the patient was treated with a diagnosis of hypocomplementemia, involving C3 and C4. Presently, the patient exhibits cutaneous lesions on the upper and lower extremities. The lesions were maculopapular erythematous, non-tender, and non-pruritic and worsened with light exposure. Our evaluation showed positive anti-double-stranded DNA, anemia, elevated erythrocyte sedimentation rate (ESR), low C3 and C4, and a positive biopsy report, confirming a diagnosis of acute SLE.
Conclusions: Monitoring complement levels and activity may serve as valuable biomarkers for disease activity and response to treatment in SLE patients. Overall, the complement system’s involvement in SLE highlights its importance in this challenging autoimmune disorder’s research and clinical management. |
|
| کلیدواژه‌های انگلیسی مقاله |
Hypocomplementemia, Complement C4, Complement C3, Systemic lupus erythematosus (SLE), Pediatrics |
|
| نویسندگان مقاله |
| Narges Lashkarbolouk
Taleghani Pediatric Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
| Mahdi Mazandarani
Taleghani Pediatric Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
| Ali Ahani Azari
Taleghani Pediatric Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
| Lobat Shahkar
Taleghani Pediatric Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
|
|
| نشانی اینترنتی |
http://jpr.mazums.ac.ir/browse.php?a_code=A-10-1217-1&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
آلرژی و ایمونولوژی بالینی |
| نوع مقاله منتشر شده |
Case Report and Review of Literature |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|