| چکیده انگلیسی مقاله |
Background: Cigarette smoking is a prevalent addictive behavior. Despite the well-known health risks, many individuals are unable to quit. One of the key factors contributing to the failure of smoking cessation efforts is the presence of craving and the tendency toward risk-taking behaviors. Noninvasive brain stimulation techniques have recently emerged as potential treatments for addiction. The present study is a pilot trial to examine the impact of tDCS targeting DLPFC on risk-taking, EEG frequency power, and their relationship with the cue-induced nicotine craving in smokers.
Methods: In this double-blind study, which is part of a larger randomized clinical trial, sixty-three cigarette smokers who met the ICD-10 criteria for tobacco addiction were enrolled. tDCS sham, left anodal/right cathodal, and right anodal/left cathodal tDCS will be applied to three participant groups. Participants were required to refrain from smoking for two hours prior to the study visit. The effects of tDCS on cue-triggered nicotine craving, certain risky decision-making tasks, and some resting-state EEG frequency power analyses were evaluated both before and after periods of tDCS (2 mA for 20 minutes) applied to the dorsolateral prefrontal cortex on five consecutive days.
Discussion: Although several studies have reported that tDCS may have beneficial effects on drug abuse by suppressing the degrees of cravings, impulsivity, and risk decision making.
However, to date, no study has evaluated the impact of tDCS on the DLPFC and its relationship with EEG frequency power characteristics. The results of this study are anticipated to represent a significant step toward improving smoking cessation efforts. The findings from this randomized controlled trial will explore the therapeutic potential of transcranial direct current stimulation (tDCS) in treating nicotine addiction among smokers. |
| کلیدواژههای انگلیسی مقاله |
Transcranial direct current stimulation, Dorsolateral prefrontal cortex, Risky decision-making behavior, Brain wave pattern, Nicotine, Craving |
| نویسندگان مقاله |
| Saba Niknamfar
Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Kamaledin Alaedini
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
| Azarakhsh Mokri
Department of Psychiatry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Eisa Nazar
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
| Raheleh Rafaiee
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
| Seyedeh Masoumeh Seyedhosseini Tamijani
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
| Seyed Hamzeh Hosseini
Psychosomatic Research Center, Sari Imam Khomeini Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Hamed Ghazvini
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
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