| چکیده انگلیسی مقاله |
Introduction: The 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is a popular recreational drug and a major source of substance abuse, which ultimately leads to sensations of well-being, elation and euphoria, moderate derealization/depersonalization, and cognitive disruptions, as well as intense sensory awareness. The mechanisms involved in memory impairment induced by MDMA are not completely understood. Methods: The current study used 40 Sprague-Dawley rats, weighted 200 to 250 g. Experiments were performed in four groups, each containing 10 rats. The first group of rats was used as the control, treated with dimethyl sulfoxide (DMSO). The second group was treated with MDMA. The third group was treated with MDMA and CGS (the adenosine A2A receptor agonist, 2-[p-(2- carboxyethyl) phenethylamino]-5′-N-ethylcarboxamidoadenosine) (CGS 21680) and the fourth group was treated with MDMA and SCH (the A2A receptor antagonist [7-(2-phenylethyl)-5-amino-2-(2-furyl-) pyrazolo-[4, 3-e]-1, 2, 4 triazolo [1,5-] pyrimidine]) (SCH 58261). The drugs in all groups were administrated intraperitoneally (i.p.) once a day for 7 days. In 5 rats of each group, following perfusion, samples were taken from hippocampi to investigate apoptosis. Accordingly, the samples were stained using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay kit, and studied by light microscopy. In other rats, fresh tissue was also removed to study the expression of bax and bcl-2 by Western blotting technique. Results: It was observed that the coadministration of MDMA with CGS reduced bax expression and prevented apoptosis of hippocampal cells. The coadministration of MDMA and SCH increased bax expression, and also increased the frequency of hippocampal cell apoptosis. Conclusion: The results of the current study showed that administration of CGS with MDMA decreased the common side effects associated with MDMA. |
| نویسندگان مقاله |
معصومه بخشایش | masoomeh bakhshayesh
cellular and molecular research center, iran university of medical sciences iums , tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
فرشته گلاب | fereshteh golab
cellular and molecular research center, iran university of medical sciences iums , tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
فاطمه کرمانیان | fatemeh kermanian
department of anatomy, school of medicine, alborz university of medical sciences, karaj, iran
مهدی مهدی زاده | mehdi mehdizadeh
cellular and molecular research center, iran university of medical sciences iums , tehran, iran; department of anatomy, school of medicine, iran university of medical sciences iums , tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
امیررضا کاتبی | amir reza katebi
department of educational psychology, faculty of psychology amp;amp; educational sciences, allameh tabataba’i university, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علامه طباطبایی (Allameh tabatabaii university)
منصوره سلیمانی | mansooreh soleimani
cellular and molecular research center, iran university of medical sciences iums , tehran, iran; department of anatomy, school of medicine, iran university of medical sciences iums , tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
فرزانه محمدزاده | farzaneh mohammadzadeh
department of anatomy, school of medicine, iran university of medical sciences iums , tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
روناک شعبانی | ronak shabani
cellular and molecular research center, iran university of medical sciences iums , tehran, iran; department of anatomy, school of medicine, iran university of medical sciences iums , tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
الهام موحد | elham movahed
department of anatomy, school of medicine, iran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
مجید کاتبی | majid katebi
department of anatomy, school of medicine, hormozgan university of medical sciences, bandar abbas, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی هرمزگان (Hormozgan university of medical sciences)
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