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Research in Molecular Medicine، جلد ۵، شماره ۲، صفحات ۰-۰
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| عنوان انگلیسی |
Effect of Lamium Album on Mitochondrial Oxidative Stress in Diabetic Rats |
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| چکیده انگلیسی مقاله |
Background: Diabetes mellitus (DM) is characterized by the presence of hyperglycemia. Lamium album is known to have antioxidant, and free radical scavenging actions. Since the role of oxidative stress and reactive oxygen species (ROS) production in the pathogenesis of diabetes or associated complications, the aim of the present study was to evaluate the mitochondrial ROS of circulating neutrophils in diabetic rats given L. album extract to understand if there is any association between mitochondrial ROS production and this plant extract administration. Materials and Methods: Twenty-one male Wistar rats were randomly divided into three groups; normal control rats; receiving daily saline, diabetic control rats; receiving daily saline, and diabetic rats treated daily with hydroalcoholic extract of L. album (100 mg/kg) for 28 days. On the 28thday of treatment, whole blood samples were obtained and mitochondrial ROS of neutrophils was measured by dihydrorhodamine (DHR) flowcytometric method. Also, fasting blood sugar (FBS) was measured. Results: Mitochondrial ROS didn’t show any significant differences among diabetic rats treated with L. album extract, diabetic control rats, and normal control rats(P=0.8). Serum glucose in diabetic control was significantly higher than normal control rats (P=0.0001). However L. album caused a remarkable decrease in serum glucose from diabetic rats (P=0.03). Conclusion: According to these findings, mitochondrial ROS seems not to be a marker for protective role of L. album on diabetes, but evaluation of extracellular ROS along with mitochondrial ROS might be more relevant to indicate L. album influence. |
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| نویسندگان مقاله |
کورش خانکی | korosh khanaki
guilan university of medical sciences
دانشگاه علوم پزشکی گیلان
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
محمود عابدین زاده | mahmood abedinzade
guilan university of medical sciences
دانشگاه علوم پزشکی گیلان
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
روح الله گازر | rouhollah gazor
guilan university of medical sciences
دانشگاه علوم پزشکی گیلان
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
محمدرضا نورس فرد | mohammadreza norasfard
guilan university of medical sciences
دانشگاه علوم پزشکی گیلان
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
رضا جعفری شکیب | reza jafari shakib
guilan university of medical sciences
دانشگاه علوم پزشکی گیلان
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-584-1&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمونولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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