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Research in Molecular Medicine، جلد ۵، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Blimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia |
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| چکیده انگلیسی مقاله |
Background: Previously, we showed that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Here, we investigated the expression of Blimp-1, a transcription factor involving in T-cell exhaustion, in patients with CLL. Methods: Peripheral blood mononuclear cells were collected from 25 untreated CLL patients and 15 sex- and age-matched normal subjects. CLL patients were clinically classified according to the Rai staging system. The relative expression of Blimp-1 mRNA was determined by quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR) after normalization with β-actin. Results: Expression of Blimp-1 mRNA was much higher in CLL patients than in normal controls (p=0.001). Moreover, Blimp-1 was higher expressed in patients with advanced clinical stages of CLL compared to those with early stages of the disease (p=0.01). Interestingly, the Blimp-1 expression was correlated with the frequencies of exhausted Tim-3+/PD-1+/CD4+ and Tim-3+/PD-1+/CD8+ T cells in CLL patients. Conclusions: Our results highlight the role of Blimp-1 transcription factor in T cell exhaustion of CLL. |
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| کلیدواژه‌های انگلیسی مقاله |
Exhausted T cell, Blimp-1, Chronic Lymphocytic Leukemia |
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| نویسندگان مقاله |
سعید تقی لو | saeid taghiloo
department of immunology, school of medicine, mazandaran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
اسماعیل اله مرادی | esmaeil allahmoradi
department of immunology, school of medicine, mazandaran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
محسن تهرانی | mohsen tehrani
department of immunology, school of medicine, mazandaran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
قاسم جان بابایی | ghasem janbabaei
gastrointestinal cancer research center, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
رامین شکرریز | ramin shekarriz
gastrointestinal cancer research center, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
حسین عسگریان عمران | hossein asgarian omran
department of immunology, school of medicine, mazandaran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-917-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمونولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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