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Basic and Clinical Neuroscience، جلد ۸، شماره ۶، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of WIN55-212-2 and Consequences of Extinction Training on Conditioned Fear Memory in PTSD Male Rats |
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| چکیده انگلیسی مقاله |
Introduction: This study investigates the effects of cannabinoid agonist WIN55-212-2 on acquisition and consolidation phases of the fear memory extinction and also on anxiety and motor activity. Methods: In this study, we used SPS & S model to induce post-traumatic stress disorder. One week after SPS, to establish a conditioned fear memory, rats received an electric foot shock within shock chamber. After 24 h, for extinction training, the rats were placed back to the chamber for 9 min, without receiving any shock. In 3 consecutive days and on days 17, 24 and 37, extinction tests were carried out and the freezing behavior was evaluated. Thirty minutes before the first three extinction tests, animals received IP injections of WIN or vehicle. Anxiety-like behavior examined with elevated plus-maze and motor activity with open field, 32 days after conditioning. Results: Exaggerated and continued conditioned fear memory observed in SPS & S group compared with shock group. IP injection of a 0.25 mg/kg dose of WIN before extinction training led to reducing fear responses in animals. Conclusion: IP injection of WIN increased acquisition or consolidation of fear memory extinction. SPS & S caused anxiety and this effect improved by the agonist (0.25 mg/kg). |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
ملیحه قاسمی | malihe ghasemi
school of biology, damghan university, damghan, iran
سازمان اصلی تایید شده: دانشگاه دامغان (Damghan university)
کتانه ابراری | kataneh abrari
department of physiology, school of biology, damghan university, damghan, iran.
سازمان اصلی تایید شده: دانشگاه دامغان (Damghan university)
ایران گودرزی | iran goudarzi
school of biology, damghan university, damghan, iran
سازمان اصلی تایید شده: دانشگاه دامغان (Damghan university)
علی رشیدی پور | ali rashidy pour
semnan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-904-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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