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Basic and Clinical Neuroscience، جلد ۹، شماره ۱، صفحات ۵۱-۵۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test |
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| چکیده انگلیسی مقاله |
Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction. Methods: To this end, the kindled animal were prepared via CA1 electrical stimulation in a semi-rapid way (12 stimulations/day). A group of animals were stimulated with LFS, 4 times at 30 s, 6 h, 24 h, and 30 h after the last kindling stimulation. Applied LFS was administered in 4 packages every 5 minutes. The packages were designed with 200 monophasic 200 monophasic square wave pulses of 0.1 ms duration at 1 Hz. The passive-avoidance test was conducted on all animals in order to measure the learning and memory behavior. Results: Hippocampal kindled rats showed deficits in learning and memory when passive avoidance test was performed. Application of LFS reversed the impairment in learning and memory behavior in kindled rats. At the same time, LFS markedly diminished kindling-induced neuronal loss and atrophy in the hippocampus. Conclusion: LFS may have some protection against seizure-induced cognitive damage in kindled rats. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
خدیجه اسماعیل پور | khadijeh esmaeilpour
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
وحید شیبانی | vahid sheibani
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
محمد شعبانی | mohammad shabani
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
جواد میرنجفی زاده | javad mirnajafi zadeh
department of physiology, faculty of medical sciences, tarbiat modares university, tehran, iran.
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)
زینب اکبرنژاد | zeinab akbarnejad
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1071-1&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-568849.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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