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Research in Molecular Medicine، جلد ۵، شماره ۳، صفحات ۰-۰
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Report of allelic variation in Helicobacter pylori dupA: A viewpoint |
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| چکیده انگلیسی مقاله |
Helicobacter pylori (H. pylori) is the pivotal cause of chronic gastritis, peptic ulcer diseases (PUD) and gastric cancer. Morphologically, the bacterium is spiral, Gram-negative and microaerophilic which survive lifespan in the human stomach in the case of weak antibiotic therapy. There is a major difference in the pattern of global prevalence of H. pylori infection based on different levels of urbanization, hygiene, sanitation, access to clean water and other socioeconomic factors. To date, many studies have attempted to find significant associations between specific gastroduodenal diseases and dupA-positive strains, but no conclusive conclusion has been declared. The main reason for these inconsistent findings is the various methodologies applied in experiments which in turn have resulted in inaccurate observation. Our analysis showed that the existence of various alleles located in the dupA cluster would be a novel explanation for different associations found between this bacterial gene and diseases. In detailed experiments examining our proposed alleles using a large number of patients can be useful to disclose a significant clinical association between H. pylori dupA-positive strains and duodenal ulcer. |
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| نویسندگان مقاله |
گلزار | golzar
tarbiat modares university, dept of bacteriology, p.o. box 14115-111, tehran, iran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)
امین طالبی بزمین ابادی | amin talebi bezmin abadi
tarbiat modares university, dept of bacteriology, p.o. box 14115-111, tehran, iran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-851-4&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عفونی |
| نوع مقاله منتشر شده |
review |
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