|
|
Anatomical Sciences Journal، جلد ۱۰، شماره ۴، صفحات ۲۴-۲۸
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Chronic and Sub-acute Effects of 3,4-methylenedioxy methamphetamine (MDMA) on Spatial Memory and Passive Avoidance Learning in Wistar Rats |
|
| چکیده انگلیسی مقاله |
Introduction: In the recent years, the use of several drugs such as cocaine and morphine has reduced, but the use of "club drugs" has increased in many countries. 3, 4-methylenedioxymethamphetamine (MDMA) which has known as ‘ecstasy’ among people has many harmful effects on serotonergic system in the brain. This system is responsible for learning and memory. In this study, we tested sub-acute and chronic effects of MDMA on spatial memory in the Morris water maze (MWM) task and passive avoidance tasks. Methods: 18 Adult male wistar rats (200-250 g) were given single or multiple injections of MDMA (10 mg/kg, IP) . Learning and spatial memory functions were assessed using passive avoidance and Morris water maze (MWM) tasks, respectively. Data was analyzed by SPSS 16 software and one- way analysis of variance (ANOVA) test. Results: The results showed that sub-acute and chronic administration of MDMA have adverse effects on escape latency, traveled distance and avoidance learning in the rats. The changes were more significant in sub-acute group. Conclusion: These data suggest that MDMA treatment impairs learning and memory performances that are more extensive in sub-acute group. |
|
| کلیدواژه‌های انگلیسی مقاله |
3, 4 Methylendioxymethamphetamine, Learning, Memory |
|
| نویسندگان مقاله |
فاطمه میرزایی | fatemeh mirzaei
anatomy department, school of medicine, hamadan university of medical sciences, hamadan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سارا سلیمانی اصل | sara soleimani asl
research center for behavioral disorders and substance abuse, hamadan university of medical sciences, hamadan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
محمد بختیار حسام شریعتی | mohammad bakhtiar hesam shariati
anatomy department, school of medicine, hamadan university of medical sciences, hamadan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
مهدی مهدی زاده | mehdi mehdizadeh
cellular amp;amp; molecular research center, faculty of advanced technology in medicne, department of anatomical sciences, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
مریم سهرابی | maryam sohrabi
anatomy department, school of medicine, hamadan university of medical sciences, hamadan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
|
|
| نشانی اینترنتی |
http://www.anatomyjournal.ir/browse.php?a_code=A-10-25-27&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Macro - Anatomy |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|