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Basic and Clinical Neuroscience، جلد ۹، شماره ۴، صفحات ۲۱۵-۲۲۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Assessing the Effects of Opioids on Pathological Memory by a Computational Model |
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| چکیده انگلیسی مقاله |
Introduction: Opioids hijack learning and memory formation mechanisms of brain and induce a pathological memory in the hippocampus. This effect is mainly mediated by modifications in glutamatergic system. Speaking more precisely, Opioids presence in a synapse inhibits blockage of N-Methyl-D-Aspartate Receptor (NMDAR) by , enhances conductance of NMDAR and thus, induces false Long-Term Potentiation (LTP). Methods: Based on experimental observations of different researchers, we developed a mathematical model for a pyramidal neuron of the hippocampus to study this false LTP. The model contains a spine of the pyramidal neuron with NMDAR, α-Amino-3-hydroxy-5-Methyl-4-isoxazole Propionic Acid Receptors (AMPARs), and Voltage-Gated Calcium Channels (VGCCs). The model also describes Calmodulin-dependent protein Kinase II (CaMKII) and AMPAR phosphorylation processes which are assumed to be the indicators of LTP induction in the synapse. Results: Simulation results indicate that the effect of inhibition of blockage of NMDARs by Mg2+ on the false LTP is not as crucial as the effect of NMDAR's conductance modification by opioids. We also observed that activation of VGCCs has a dominant role in inducing pathological LTP. Conclusion: Our results confirm that preventing this pathological LTP is possible by three different mechanisms: 1. By decreasing NMDAR's conductance; 2. By attenuating VGCC's mediated current; and 3. By enhancing glutamate clearance rate from the synapse. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Mehdi Borjkhani
Motor Control and Computational Neuroscience Laboratory, School of Electrical & Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.
| Fariba Bahrami
Motor Control and Computational Neuroscience Laboratory, School of Electrical & Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.
| Mahyar Janahmadi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1150-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Computational Neuroscience |
| نوع مقاله منتشر شده |
Original |
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