| چکیده انگلیسی مقاله |
Introduction: Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor β (TGF-β) between patients with major depressive disorder and healthy controls. Methods: Blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. The subjects were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum concentrations of IL-21, IL-17, and TGF-β were assessed using ELISA. Results: The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-β level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs. 174.8±27.20 pg/mL, (P< 0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15 pg/mL (P>0.05). Conclusion: Considering pro-inflammatory cytokines, current results support the associationof inflammatory response and depressive disorder. So, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts. |
| نویسندگان مقاله |
محمد حسن دوامی | mohammad hasan davami
department of immunology and microbiology, school of medicin, jahrom university of medical sciences, jahrom, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جهرم (Jahrom university of medical sciences)
رسول بهارلو | rasoul baharlou
department of immunology and microbiology, school of medicin, jahrom university of medical sciences, jahrom, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جهرم (Jahrom university of medical sciences)
عباس احمدی وسمه جانی | abbas ahmadi vasmehjani
department of immunology and microbiology, school of medicin, jahrom university of medical sciences, jahrom, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جهرم (Jahrom university of medical sciences)
احمد غنی زاده | ahmad ghanizadeh
department of psychiatry, school of medicin, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
میترا کشتکار | mitra keshtkar
department of psychiatry, school of medicin, jahrom university of medical sciences, jahrom, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جهرم (Jahrom university of medical sciences)
ایمان دژکام | iman dezhkam
department of student research committee, school of medicine, jahrom university of medical sciences, jahrom, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جهرم (Jahrom university of medical sciences)
محمدرضا آتش زر | mohammad reza atashzar
department of student research committee, school of medicine, jahrom university of medical sciences, jahrom, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جهرم (Jahrom university of medical sciences)
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