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Basic and Clinical Neuroscience، جلد ۶، شماره ۴، صفحات ۲۳۹-۲۵۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Effects of Memantine, an NMDA Antagonist, on Metabolic Syndromes in Female NMRI Mice |
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| چکیده انگلیسی مقاله |
Introduction: The brain glutamate neurotransmitter system and its NMDA receptors in the nucleus accumbens play an important role in the incidence of the phenomena of sensitivity and addiction. The present study examined the inhibitory effect of glutamate NMDA receptors in the nucleus accumbens in response to chronic stress. Methods: After the unilateral and bilateral cannula placement in the nucleus accumbens, one group of the animals received different intra-accumbens doses of memantine (0.1, 0.5 and 1 µg/mouse) 5 minutes before receiving the electric shock stress at their soles (using a Communication Box) and the other group received intraperitoneal doses of memantine (0.1, 0.5 and 1mg/kg) 30 minutes before receiving the same shock. Chronic stress increased the animals' plasma corticosterone, food and water intake and weight and reduced their defecation rates and eating latency. Results: The intraperitoneal administration of memantine increased plasma corticosterone, water intake, fecal weight and eating latency, but had no effect on food intake or weight. The dose and site-dependent intra-accumbens administration of memantine either exacerbated the effects of stress on plasma corticosterone levels and water and food intake, or else had no effect on these parameters. Furthermore, the administration of memantine had no effect on animal’s weight and inhibited the effects of stress on fecal weight and eating latency. Discussion: The inhibition of glutamate NMDA receptors in the nucleus accumbens can inhibit and/or exacerbate the dose and site-dependent effects of chronic stress, with gender playing a significant role in producing this effect. |
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| کلیدواژه‌های انگلیسی مقاله |
NMDA receptors, Nucleus accumbens, Stress, Memantine, Mouse |
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| نویسندگان مقاله |
ناصر اصانلو | naser osanloo
neuroscience research center, baqiyatallah a.s. university of medical sciences, tehran, iran.
ناهید سراحیان | nahid sarahian
neuroscience research center, baqiyatallah a.s. university of medical sciences, tehran, iran.
حمیرا زردوز | homeira zardooz
department of physiology, school of medicine, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
هدایت صحرایی | hedayat sahraei
neuroscience research center, baqiyatallah a.s. university of medical sciences, tehran, iran.
محمد صحرایی | mohammad sahraei
faculty of dentistry, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
بهاره صادقی | bahareh sadeghi
neuroscience research center, baqiyatallah a.s. university of medical sciences, tehran, iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-761-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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