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Basic and Clinical Neuroscience، جلد ۶، شماره ۴، صفحات ۲۵۳-۲۶۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Successful Reconstruction of Nerve Defects Using Distraction Neurogenesis with a New Experimental Device |
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| چکیده انگلیسی مقاله |
Introduction: Repair of peripheral nerve injuries is an intensive area of challenge and research in modern reconstructive microsurgery. Intensive research is being carried out to develop effective alternatives to the standard nerve autografting, avoiding its drawbacks. The aim of the study was to evaluate the effectiveness of a newly designed mechanical device for the reconstruction of the sciatic nerve in rats in comparison to nerve autografting and to assess the pain during the period of distraction neurogenesis. Methods: Fourteen Sprague Dawley rats were used and randomly assigned into 2 groups with 7 rats in each group group A (Nerve Autografting group) in which a 10-mm segment of the sciatic nerve was resected and rotated 180 degrees, then primary end-to-end neurorrhaphy was performed in the reverse direction group B (Nerve Lengthening group) in which the mechanical device was inserted after surgical resection of 10 mm of the sciatic nerve, then secondary endto- end neurorrhaphy was performed after completing the nerve lengthening. Thirteen weeks later, assessment of the functional sciatic nerve recovery using static sciatic index (SSI) was performed. Furthermore, fourteen weeks after the nerve resection, assessment of the nerve regeneration with electrophysiological study and histological analysis were performed. Also, gastrocnemius wet weight was measured. For pain assessment in group B, Rat Grimace Scale (RGS) score was used. Results: Significantly better functional recovery rate (using the SSI) was reported in the nerve lengthening group in comparison to autografting group. Also, a statistically significant higher nerve conduction velocity was detected in the nerve lengthening group. On histological analysis of the distal nerve section at 3 mm distal to the nerve repair site, significant myelin sheath thickness was detected in the nerve lengthening group. Discussion: Distraction neurogenesis with the new experimental device is a reliable therapeutic method for the reconstruction of nerve defects. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
محمد عبدالحمید علی یوسف | mohamed abdelhamid ali yousef
experimental surgery and microsurgery research unit, department of general surgery, university of pavia, v.le golgi 19, 27100, pavia, italy.
paolo dionigi | paolo dionigi
organization
stefania marconi | stefania marconi
organization
آلبرتو calligaro | alberto calligaro
organization
antonia icaro cornaglia | antonia icaro cornaglia
organization
enrico alfonsi | enrico alfonsi
organization
ferdinando auricchio | ferdinando auricchio
organization
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-721-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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