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Basic and Clinical Neuroscience، جلد ۶، شماره ۴، صفحات ۲۸۵-۲۹۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test |
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| چکیده انگلیسی مقاله |
Introduction: Borago officinalis flower (borage) is a known sedative in herbal medicine the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. Methods: Fifty-six adult male albino Wistar rats were randomly divided into seven groups: Control groups of A (intact), B (saline), and C (Positive control) plus test groups of D, E, F, and G (n=8). The groups D, E , and F received 6.25, 12.5, and 25 mg/kg, Borago officinalis flower hydroalcholic extract before the test, respectively but group G received 25 mg/kg borage extract and aspirin before the test. A biphasic pain was induced by injection of formalin 1%. The obtained data were analyzed by SPSS software ver. 17 employing statistical tests of Kruskal- Wallis and Mann-Whitney. The results were expressed as mean±SD. Statistical differences were considered significant at P< 0.05. Results: The results revealed that the acute and chronic pain behavior score in test groups of D, E, F, and G significantly decreased compared to groups A and B, but this score did not show any difference compared to group C. Moreover, chronic pain behavior score in group G was significantly lower than all other groups. Discussion: The results indicated that Borago officinalis hydroalcoholic extract affects the acute and chronic pain behavior response in formaline test male rats. |
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| کلیدواژه‌های انگلیسی مقاله |
Formalin test, Rat, Pain behavior, Borago officinalis |
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| نویسندگان مقاله |
محمدرضا شهرکی | mohammad reza shahraki
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
مهدیه ahmadimoghadm | mahdieh ahmadimoghadm
local studies amp;amp; specialty services of jahad-e-daneshgahi, sistan and baluchistan branch, zahedan, iran.
احمدرضا شهرکی | ahmad reza shahraki
zahedan university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-717-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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