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Basic and Clinical Neuroscience، جلد ۶، شماره ۳، صفحات ۱۸۵-۱۹۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Vitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats |
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| چکیده انگلیسی مقاله |
Introduction: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitive decline. Methods: 24 female Wistar rats weighing 180-220 g were used in this study. The animals were ovariectomized and randomly divided into four groups including, control and two groups which received 8 and 80 mg/kg Vitex agnus castus (VAC) ethanolic extract orally. The last groups were treated with 40 μg/kg of estradiol valerat. Step-through passive avoidance (STPA) test was used for the evaluation of learning and memory. The hippocampal estrogen receptor α (ERα) expression was measured using Real-Time PCR. Results: The results demonstrated that VAC extract or estradiol had better performance on stepthrough passive avoidance test than control group (all P< 0.05). Moreover, administration of either estradiol or VAC extract increased the hippocampal mRNA level of ERα and prevented the decrease in uterine weight of ovariectomized rats. Discussion: Based on our data, VAC extract improves learning and memory in ovariectomized rats. The positive effect of VAC extract on learning and memory is possibly associated with an increase in ERα gene expression in the hippocampal formation. |
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| نویسندگان مقاله |
محمد الله توکلی | mohammad allahtavakoli
نجمه هنری | najmeh honari
ایران پور ابولی | iran pourabolli
محمد کاظمی عرب آبادی | mohammad kazemi arababadi
حسین غفاریان | hossein ghafarian
علی روحبخش | ali roohbakhsh
علی اسماعیلی ندیمی | ali esmaeili nadimi
علی شمسی زاده | ali shamsizadeh
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-147-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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