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Basic and Clinical Neuroscience، جلد ۶، شماره ۱، صفحات ۲۱-۲۸
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| عنوان انگلیسی |
Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats |
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| چکیده انگلیسی مقاله |
Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Methods: Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafaxine or its vehicle injection. Then final withdrawal behaviours and tail flick test were performed. Results: Combination of chronic methadone substitution and venlafaxine administration, significantly reduced freezing behaviour of spontaneous morphine withdrawal syndrome (p< 0.01, 379±144%). Chronic methadone administration (p< 0.05, 35±8% difference with venlafaxine treated group) induced hyperalgesia. A positive correlation (p=0.001, +63%) was observed between the animals final freezing scores and their response latencies to the painful stimulus. Discussion: Combination of chronic methadone and venlafaxine administrations reduces freezing withdrawal behaviour. Further investigations on analgesic interventions are needed to overcome this hyperalgesia. |
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| نویسندگان مقاله |
میثم فدایی kenarsary | meisam fadaei kenarsary
tea organization rest house, kelarabad, mazandaran, i.r.iran, postal code 4673119573
یعقوب فربود | yaghoob farbood
ahvaz jundishapur university of medical sciences ajums , school of medicine, department of pharmacology, physiology research center, ahvaz, i.r. iran. postal code 61357-33118
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)
سید محمد تقی منصوری | seyed mohammad taghi mansouri
ahvaz jundishapur university of medical sciences ajums , school of medicine, department of pharmacology, physiology research center, ahvaz, i.r. iran. postal code 61357-33118
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)
هادی فتحی مقدم | hadi fathi moghaddam
84 mehran street, melirah ave, ahvaz, iran. po box 61357-33118
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-581-2&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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